Neuropeptide B (NPB) Antibody
351€ (100 µg)
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935106861
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name
Neuropeptide B (NPB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx376130
tested applications
ELISA, WB
Description
Neuropeptide B (NPB) Antibody is a Rabbit Polyclonal antibody against Neuropeptide B (NPB).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuropeptide B (NPB) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NG41 |
| Gene ID | 256933 |
| OMIM | 607996 |
| Alias | NPBWR1,GPR7,G protein-coupled receptor 7,neuropeptides B/W receptor type 1 |
| Background | Antibody anti-NPBWR1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
NPBWR1, also known as GPR7, is a G protein-coupled receptor that binds neuropeptide B (NPB) and neuropeptide W (NPW), two endogenous ligands involved in energy regulation, stress, and emotional behaviors. NPBWR1 is predominantly expressed in the central nervous system (CNS), including the hypothalamus, amygdala, and brainstem, where it regulates feeding behavior, stress responses, and neuroendocrine function. Activation of NPBWR1 couples to Gi/o proteins, inhibiting adenylate cyclase activity, which reduces cAMP levels and modulates neuronal excitability. NPBWR1 is implicated in regulating appetite and body weight, as its activation suppresses feeding behavior and influences energy balance. Additionally, NPBWR1 modulates emotional responses, including anxiety and stress-related behaviors, by acting on circuits in the limbic system. Dysregulation of NPBWR1 signaling is linked to obesity, anxiety disorders, and mood dysregulation. Targeting NPBWR1 holds therapeutic potential for metabolic disorders, anxiety, and stress-related conditions due to its role in energy and emotional homeostasis.
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