Neuropeptide B (NPB) Antibody

Background

NPBWR1, also known as GPR7, is a G protein-coupled receptor that binds neuropeptide B (NPB) and neuropeptide W (NPW), two endogenous ligands involved in energy regulation, stress, and emotional behaviors. NPBWR1 is predominantly expressed in the central nervous system (CNS), including the hypothalamus, amygdala, and brainstem, where it regulates feeding behavior, stress responses, and neuroendocrine function. Activation of NPBWR1 couples to Gi/o proteins, inhibiting adenylate cyclase activity, which reduces cAMP levels and modulates neuronal excitability. NPBWR1 is implicated in regulating appetite and body weight, as its activation suppresses feeding behavior and influences energy balance. Additionally, NPBWR1 modulates emotional responses, including anxiety and stress-related behaviors, by acting on circuits in the limbic system. Dysregulation of NPBWR1 signaling is linked to obesity, anxiety disorders, and mood dysregulation. Targeting NPBWR1 holds therapeutic potential for metabolic disorders, anxiety, and stress-related conditions due to its role in energy and emotional homeostasis.