NCKAP - NCK associated protein | Elisa - Clia - Antibody - Protein
Family main features
Background
NCKAP (NCK-associated protein) is a critical component of the WAVE (WASP family Verprolin-homologous protein) complex involved in the regulation of the actin cytoskeleton. This protein is vital for various cellular processes, including cell motility, adhesion, and signaling. NCKAP, through its role in the WAVE complex, links extracellular signals to actin polymerization, essential for cell migration and morphogenesis. Dysregulation of NCKAP is associated with several diseases, including cancer and neurological disorders.
Protein Structure
NCKAP is a multidomain protein with several critical regions:
- N-terminal domain: This domain is involved in interactions with other components of the WAVE complex.
- Central region: It contains binding sites for actin and other regulatory proteins.
- C-terminal domain: This domain often mediates interactions with signaling molecules, including the NCK adaptor proteins.
NCKAP proteins are large, typically over 1,000 amino acids, and their structure allows them to act as scaffolds, bringing together various proteins to regulate actin dynamics.
Classification and Subtypes
NCKAP proteins are part of a family that includes different isoforms:
- NCKAP1 (Nap1): Predominantly expressed in neurons and involved in brain development and function.
- NCKAP1L (Hem1): Expressed in hematopoietic cells and involved in immune cell function.
Function and Biological Significance
- Actin Cytoskeleton Regulation: NCKAP, as part of the WAVE complex, promotes actin polymerization by activating the Arp2/3 complex, which is crucial for the formation of branched actin networks.
- Cell Migration and Morphogenesis: NCKAP is essential for cell movement and shape changes, processes critical during development and tissue repair.
- Signal Transduction: It mediates signals from cell surface receptors to the actin cytoskeleton, facilitating cellular responses to external stimuli.
Clinical Issues
- Cancer: Abnormal expression or mutations in NCKAP proteins can contribute to cancer progression by affecting cell migration and invasion.
- Neurological Disorders: Alterations in NCKAP1 function are linked to neurodevelopmental disorders and intellectual disabilities due to its role in neuronal migration and synapse formation.
- Immune System Disorders: Mutations in NCKAP1L (Hem1) can lead to immunodeficiencies by disrupting actin dynamics in immune cells.
Summary
NCKAP proteins are crucial regulators of the actin cytoskeleton, participating in essential cellular functions such as migration, adhesion, and signaling. These proteins act as scaffolds within the WAVE complex, promoting actin polymerization in response to extracellular signals. The proper function of NCKAP proteins is vital for normal cellular processes, and their dysregulation is implicated in various diseases, including cancer, neurological disorders, and immunodeficiencies. Understanding the structure and function of NCKAP proteins is fundamental for elucidating their role in health and disease.
NCKAP1 Recommended name:
NCK associated protein 1 (NCKAP1)
Aliases for NCKAP1
HEM2,NAP1,NAP125,p125Nap1,Membrane-associated protein HEM-2
NCKAP1L Recommended name:
NCK associated protein 1 like (NCKAP1L)
Aliases for NCKAP1L
HEM1,IMD72,Hematopoietic protein 1,Membrane-associated protein HEM-1
NCKAP5 Recommended name:
NCK associated protein 5 (NCKAP5)
Aliases for NCKAP5
ERIH,NAP5,ERIH1,ERIH2,Peripheral clock protein,
NCKAP5L Recommended name:
NCK associated protein 5 like (NCKAP5L)
Aliases for NCKAP5L
Cep169,FP1193,KIAA1602,NCKAP5-like,Centrosomal protein of 169 kDa
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, Proteins and Peptides, ELISA Kits) relacionados con NCKAP - NCK associated protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 16 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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immunoassays
| provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | NCKAP1 | abx381706 | Human NCK Associated Protein 1 (NCKAP1) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.065 ng/ml | 715 | 96 tests | Q9Y2A7 | RUO |
| Abbexa | NCKAP1L | abx534669 | Human Nck-associated protein 1-like (NCKAP1L) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | P55160 | RUO | ||
| Abbexa | NCKAP5 | abx534668 | Human Nck-associated protein 5 (NCKAP5) ELISA Kit | Human | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | O14513 | RUO | ||
| Abbexa | NCKAP5L | abx388133 | Human KIAA1602 (NCKAP5L) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 715 | 96 tests | Q9HCH0 | RUO |
| Abbexa | NCKAP1 | abx389992 | Mouse Nck-associated protein 3 (NCKAP1) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 715 | 96 tests | P28660 | RUO |
| Abbexa | NCKAP5L | abx534664 | Mouse Nck-associated protein 5-like (NCKAP5L) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q6GQX2 | RUO | ||
| Abbexa | NCKAP1 | abx391670 | Rat Nck-associated protein 1 (NCKAP1) ELISA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 715 | 96 tests | P55161 | RUO |
Primary Antibodies
| provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | NCKAP1 | abx431956 | Nck-Associated Protein 3 (NCKAP1) Antibody | Polyclonal | Goat | Nck-Associated Protein 3 (NCKAP1) | IgG | Unconjugated | P-ELISA | 416 | 200 µl | RUO | ||
| FineTest | NCKAP1 | FNab05585 | anti- NCKAP1 antibody | human | polyclonal | Rabbit | NCK-associated protein 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q9Y2A7 | RUO | |
| Abbexa | NCKAP1 | abx032664 | Nck-Associated Protein 3 (NCKAP1) Antibody | Human | Polyclonal | Rabbit | Nck-Associated Protein 3 (NCKAP1) | IgG | Unconjugated | ELISA, WB | 292.5 | 80 µl | Q9Y2A7 | RUO |
| Abbexa | NCKAP1 | abx235585 | Nck-Associated Protein 3 (NCKAP1) Antibody | Human | Polyclonal | Rabbit | Nck-Associated Protein 3 (NCKAP1) | IgG | Unconjugated | ELISA, WB, IHC | 364 | 100 µg | Q9Y2A7 | RUO |
| Abbexa | NCKAP1 | abx213880 | Nck-associated protein 3 (NCKAP1) Antibody | Human | Polyclonal | Rabbit | Nck-associated protein 3 (NCKAP1) | IgG | Unconjugated | ELISA, IHC | 260 | 50 µl | Q9Y2A7 | RUO |
| Abbexa | NCKAP1 | abx114032 | Nck-Associated Protein 1 (NCKAP1) Antibody | Human | Polyclonal | Rabbit | Nck-Associated Protein 1 (NCKAP1) | IgG | Unconjugated | ELISA, WB, IHC | 637 | 100 µl | Q9Y2A7 | RUO |
| Abbexa | NCKAP1 | abx213879 | Nck-associated protein 3 (NCKAP1) Antibody | Human | Polyclonal | Rabbit | Nck-associated protein 3 (NCKAP1) | IgG | Unconjugated | ELISA, IHC | 260 | 50 µl | Q9Y2A7 | RUO |
| Abbexa | NCKAP1 | abx126227 | Nck-Associated Protein 3 (NCKAP1) Antibody | Human | Polyclonal | Rabbit | Nck-Associated Protein 3 (NCKAP1) | IgG | Unconjugated | ELISA, WB | 195 | 20 µl | Q9Y2A7 | RUO |
Proteins and Peptides
| provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | NCKAP1 | abx616891 | Nck-Associated Protein 3 (NCKAP1) Peptide | Synthetic | Unconjugated | P-ELISA | 175.5 | 100 µg |
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