Nck-Associated Protein 3 (NCKAP1) Antibody
292.5€ (80 µl)
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Name
Nck-Associated Protein 3 (NCKAP1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032664
Tested Applications
ELISA, WB
Description
NCKAP1 Antibody is a Rabbit Polyclonal antibody against NCKAP1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nck-Associated Protein 3 (NCKAP1) Immunogen: KLH-conjugated synthetic peptide between 631-659 amino acids from the Central region of human NCKAP1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 129 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2A7 |
| Alias | HEM2,NAP1,NAP125,p125Nap1,Membrane-associated protein HEM-2 |
| Background | Antibody anti-NCKAP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
NCK associated protein 1 (NCKAP1) is an actin-regulatory protein that interacts with NCK adapter proteins and plays a crucial role in regulating cytoskeletal dynamics in various cell types NCKAP1 activates the Arp2/3 complex to promote the formation of branched actin filaments, facilitating the movement of cells and the establishment of cellular polarity This function is vital for processes like cell migration, adhesion, and tissue development, particularly in immune cells such as T cells and macrophages, where it regulates key immune responses such as synapse formation and phagocytosis NCKAP1 also contributes to the remodeling of the cytoskeleton in neurons, where it affects synaptic function and plasticity, which are critical for learning and memory However, alterations in NCKAP1 expression or function have been linked to a range of diseases, including immune disorders, cancer metastasis, and neurodevelopmental disorders Abnormal actin dynamics due to NCKAP1 dysregulation can impair immune cell function and facilitate the invasive capabilities of cancer cells, making it an important target for therapeutic strategies aimed at treating inflammatory diseases and controlling cancer metastasis
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