Mouse Nck-associated protein 3 (NCKAP1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse Nck-associated protein 3 (NCKAP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx389992
tested applications
ELISA
Description
Mouse Nck-associated protein 3 (NCKAP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse NCKAP1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Nck-associated protein 3 (NCKAP1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P28660 |
| Gene ID | 50884 |
| Alias | HEM2,NAP1,NAP125,p125Nap1,Membrane-associated protein HEM-2 |
| Background | Elisa kits for NCKAP1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
NCK associated protein 1 (NCKAP1) is an actin-regulatory protein that interacts with NCK adapter proteins and plays a crucial role in regulating cytoskeletal dynamics in various cell types NCKAP1 activates the Arp2/3 complex to promote the formation of branched actin filaments, facilitating the movement of cells and the establishment of cellular polarity This function is vital for processes like cell migration, adhesion, and tissue development, particularly in immune cells such as T cells and macrophages, where it regulates key immune responses such as synapse formation and phagocytosis NCKAP1 also contributes to the remodeling of the cytoskeleton in neurons, where it affects synaptic function and plasticity, which are critical for learning and memory However, alterations in NCKAP1 expression or function have been linked to a range of diseases, including immune disorders, cancer metastasis, and neurodevelopmental disorders Abnormal actin dynamics due to NCKAP1 dysregulation can impair immune cell function and facilitate the invasive capabilities of cancer cells, making it an important target for therapeutic strategies aimed at treating inflammatory diseases and controlling cancer metastasis
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