KPNB1 - karyopherin subunit beta 1 | Elisa - Clia - Antibody - Protein

Family main features

Background

Karyopherin Subunit Beta 1 (KPNB1), also known as Importin-β1, is a critical component of the nuclear transport system, responsible for the translocation of proteins, RNAs, and ribonucleoprotein complexes across the nuclear envelope. This process is essential for maintaining cellular homeostasis and regulating gene expression. KPNB1 operates as a transport receptor that facilitates the movement of cargo molecules through the nuclear pore complex (NPC) by recognizing and binding to nuclear localization signals (NLS) on cargo proteins, either directly or via adaptor proteins such as Karyopherin Subunit Alpha (KPNA). The directionality of transport is regulated by the RanGTPase system, ensuring proper cargo delivery to and from the nucleus.


Protein Structure

KPNB1 is characterized by several functional domains that enable its role in nuclear transport:

  • N-terminal HEAT Repeats: These tandemly arranged alpha-helical motifs create a superhelical structure that provides binding sites for various cargoes and adaptor proteins, including KPNA and NLS-containing proteins.
  • Central HEAT Repeats: These repeats form the core of KPNB1 and contribute to its flexibility and ability to interact with a wide range of cargoes.
  • C-terminal Domain: Involved in binding to the RanGTPase, which regulates cargo release and the directionality of transport through the NPC.


Classification and Subtypes

KPNB1 is a member of the karyopherin-β family, which includes several other transport receptors:

  • Importin-β (KPNB1): The primary karyopherin-β family member responsible for nuclear import of a diverse array of cargoes.
  • Transportin (TNPO1): Mediates the nuclear import of hnRNP proteins and other RNA-binding proteins.
  • Exportins (XPO): Facilitate the nuclear export of proteins and RNAs, operating in the reverse direction to importins.


Function and Biological Significance

KPNB1 plays several critical roles in cellular and physiological processes:

  • Nuclear Import: KPNB1 mediates the import of a wide variety of NLS-containing proteins into the nucleus, which is essential for regulating gene expression, DNA replication, and cell cycle progression.
  • Signal Transduction: By importing signaling molecules and transcription factors, KPNB1 ensures that extracellular signals are properly relayed to the nucleus, facilitating appropriate cellular responses.
  • Cell Cycle Regulation: KPNB1 transports cell cycle regulators into the nucleus, thereby controlling the progression and regulation of the cell cycle.
  • Development and Differentiation: KPNB1-mediated import of transcription factors and other regulatory proteins is crucial for cellular differentiation and organismal development.
  • Response to Stress: KPNB1 plays a role in the nuclear import of stress response proteins, helping cells adapt to and survive adverse conditions.


Clinical Issues

Alterations in KPNB1 function or expression are associated with various diseases:

  • Cancer: Overexpression or dysregulation of KPNB1 has been linked to several types of cancer, including breast, lung, and colorectal cancers. KPNB1 may facilitate the nuclear import of oncogenic proteins and disrupt normal cell cycle regulation.
  • Viral Infections: Some viruses exploit the KPNB1 pathway to import their proteins into the nucleus, aiding in viral replication and pathogenesis. For instance, KPNB1 is involved in the nuclear import of HIV-1 pre-integration complexes.
  • Neurodegenerative Diseases: Impaired nuclear transport, including that mediated by KPNB1, is implicated in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS).
  • Developmental Disorders: Mutations or dysregulation of KPNB1 can lead to developmental abnormalities and congenital disorders due to impaired nuclear import of essential regulatory proteins.


Summary

Karyopherin Subunit Beta 1 (KPNB1) is a key nuclear transport receptor responsible for the import of NLS-containing proteins into the nucleus. Structurally, KPNB1 features N-terminal and central HEAT repeats for cargo binding, and a C-terminal domain for interaction with RanGTPase, ensuring proper transport directionality. KPNB1 is essential for nuclear import, signal transduction, cell cycle regulation, development, and stress response. Dysregulation of KPNB1 is linked to cancer, viral infections, neurodegenerative diseases, and developmental disorders. Understanding the roles and mechanisms of KPNB1 in nuclear transport is crucial for developing therapeutic strategies for these conditions.

KPNB1 Recommended name:

karyopherin subunit beta 1 (KPNB1)

Aliases for KPNB1

KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, Importin subunit beta-1

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con KPNB1 - karyopherin subunit beta 1

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaKPNB1abx494714Human Importin Subunit Beta-1 (KPNB1) CLIA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.781 ng/ml - 50 ng/ml< 0.28 ng/ml84596 testsRUO
AbbexaKPNB1abx259640Human Importin Subunit Beta-1 (KPNB1) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml71596 testsRUO
AbbexaKPNB1abx528309Mouse Importin Subunit Beta-1 (KPNB1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP70168RUO
AbbexaKPNB1abx528310Rat Importin Subunit Beta-1 (KPNB1) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP52296RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
AbbexaKPNB1abx173238Importin Subunit Beta-1 (KPNB1) AntibodyHumanMonoclonalMouseImportin Subunit Beta-1 (KPNB1)UnconjugatedWB, IHC, IF/ICC787.51 mlRUO
AbbexaKPNB1abx346226Importin Subunit Beta-1 (KPNB1) Antibody (Biotin)HumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)BiotinELISA25050 µlQ14974RUO
AbbexaKPNB1abx346225Importin Subunit Beta-1 (KPNB1) Antibody (FITC)HumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)FITC25050 µlQ14974RUO
AbbexaKPNB1abx346224Importin Subunit Beta-1 (KPNB1) Antibody (HRP)HumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)HRPELISA25050 µlQ14974RUO
AbbexaKPNB1abx033002Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedELISA, WB, IHC, FCM281.2580 µlQ14974RUO
AbbexaKPNB1abx128252Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedWB, IHC, IF/ICC275100 µlQ14974RUO
AbbexaKPNB1abx346223Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedELISA, WB, IHC25050 µlQ14974RUO
AbbexaKPNB1abx113309Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedELISA, WB, IHC612.5100 µlQ14974RUO
AbbexaKPNB1abx124100Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedWB, IHC, IF/ICC17520 µlQ14974RUO
AbbexaKPNB1abx038324Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaKPNB1abx214947Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedELISA, IHC25050 µlQ14974RUO
AbbexaKPNB1abx234305Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalRabbitImportin Subunit Beta-1 (KPNB1)UnconjugatedELISA, WB, IHC350100 µgQ14974RUO
AbbexaKPNB1abx431357Importin Subunit Beta-1 (KPNB1) AntibodyHumanPolyclonalGoatImportin Subunit Beta-1 (KPNB1)UnconjugatedP-ELISA, WB, IHC, IF/ICC, FCM387.5200 µlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaKPNB1abx262480karyopherin beta 1 ProteinRecombinantUnconjugatedSDS-PAGE2252 µgQ14974RUO
AbbexaKPNB1abx166946Human Importin Subunit Beta-1 (KPNB1) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgRUO

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