Importin Subunit Beta-1 (KPNB1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Importin Subunit Beta-1 (KPNB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234305
tested applications
ELISA, WB, IHC
Description
Importin Subunit Beta-1 (KPNB1) Antibody is a polyclonal antibody against Importin Subunit Beta-1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Importin Subunit Beta-1 (KPNB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14974 |
| Gene ID | 3837 |
| OMIM | 602738 |
| Alias | KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1 |
| Background | Antibody anti-KPNB1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
KPNB1, also known as importin-β1, is a central nuclear transport receptor that mediates the translocation of proteins and RNA through the nuclear pore complex (NPC). It functions by binding cargo proteins either directly or through adaptor proteins such as karyopherin-α subunits. KPNB1 facilitates both nuclear import and export, utilizing Ran GTPase gradients to regulate transport directionality. It plays a key role in cellular processes such as gene regulation, mitosis, and stress responses. KPNB1 is widely expressed and is essential for embryonic development, cell cycle progression, and nucleocytoplasmic shuttling. Dysregulation of KPNB1 has been linked to cancer progression, where it enhances nuclear import of oncogenic transcription factors and survival regulators. It is also involved in viral replication, mediating the nuclear entry of viral proteins. Knockdown studies reveal its indispensability for cell viability, nuclear organization, and maintaining proper cellular function.
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