Human Importin Subunit Beta-1 (KPNB1) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Human Importin Subunit Beta-1 (KPNB1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx494714
tested applications
CLIA
Description
Human Importin Subunit Beta-1 (KPNB1) CLIA Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Importin Subunit Beta-1 (KPNB1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.781 ng/ml - 50 ng/ml |
| Sensitivity | < 0.28 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1 |
| Background | CLIA Kits KPNB1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
KPNB1, also known as importin-β1, is a central nuclear transport receptor that mediates the translocation of proteins and RNA through the nuclear pore complex (NPC). It functions by binding cargo proteins either directly or through adaptor proteins such as karyopherin-α subunits. KPNB1 facilitates both nuclear import and export, utilizing Ran GTPase gradients to regulate transport directionality. It plays a key role in cellular processes such as gene regulation, mitosis, and stress responses. KPNB1 is widely expressed and is essential for embryonic development, cell cycle progression, and nucleocytoplasmic shuttling. Dysregulation of KPNB1 has been linked to cancer progression, where it enhances nuclear import of oncogenic transcription factors and survival regulators. It is also involved in viral replication, mediating the nuclear entry of viral proteins. Knockdown studies reveal its indispensability for cell viability, nuclear organization, and maintaining proper cellular function.
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