Mouse Importin Subunit Beta-1 (KPNB1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for KPNB1
proveedor
Abbexareference
abx528309Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Importin Subunit Beta-1 (KPNB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Importin subunit beta-1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
KPNB1, also known as importin-β1, is a central nuclear transport receptor that mediates the translocation of proteins and RNA through the nuclear pore complex (NPC). It functions by binding cargo proteins either directly or through adaptor proteins such as karyopherin-α subunits. KPNB1 facilitates both nuclear import and export, utilizing Ran GTPase gradients to regulate transport directionality. It plays a key role in cellular processes such as gene regulation, mitosis, and stress responses. KPNB1 is widely expressed and is essential for embryonic development, cell cycle progression, and nucleocytoplasmic shuttling. Dysregulation of KPNB1 has been linked to cancer progression, where it enhances nuclear import of oncogenic transcription factors and survival regulators. It is also involved in viral replication, mediating the nuclear entry of viral proteins. Knockdown studies reveal its indispensability for cell viability, nuclear organization, and maintaining proper cellular function.
Características del producto
category
ELISA Kits
immunogen target
Importin Subunit Beta-1 (KPNB1)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
KPNB1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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