Human Importin Subunit Beta-1 (KPNB1) Protein
234€ (10 µg)
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935106861
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name
Human Importin Subunit Beta-1 (KPNB1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166946
tested applications
WB, SDS-PAGE
Description
Human Importin Subunit Beta-1 (KPNB1) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Importin Subunit Beta-1 (KPNB1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 50.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala21-Glu441 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1 |
| Background | Protein KPNB1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KPNB1, also known as importin-β1, is a central nuclear transport receptor that mediates the translocation of proteins and RNA through the nuclear pore complex (NPC). It functions by binding cargo proteins either directly or through adaptor proteins such as karyopherin-α subunits. KPNB1 facilitates both nuclear import and export, utilizing Ran GTPase gradients to regulate transport directionality. It plays a key role in cellular processes such as gene regulation, mitosis, and stress responses. KPNB1 is widely expressed and is essential for embryonic development, cell cycle progression, and nucleocytoplasmic shuttling. Dysregulation of KPNB1 has been linked to cancer progression, where it enhances nuclear import of oncogenic transcription factors and survival regulators. It is also involved in viral replication, mediating the nuclear entry of viral proteins. Knockdown studies reveal its indispensability for cell viability, nuclear organization, and maintaining proper cellular function.
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