Family main features
Interleukin 22 (IL-22) is a cytokine that belongs to the IL-10 family of cytokines. It plays a critical role in the innate and adaptive immune systems, particularly at epithelial barriers such as the skin, lungs, intestines, and liver. IL-22 is unique in that it primarily targets non-hematopoietic cells (e.g., epithelial cells) rather than immune cells. It promotes tissue protection, regeneration, and defense against pathogens, particularly in the context of infections and inflammatory diseases. IL-22 is primarily produced by a subset of CD4+ T cells, including Th17, Th22 cells, natural killer (NK) cells, and innate lymphoid cells (ILCs).
The role of IL-22 is highly context-dependent. While it contributes to maintaining epithelial integrity and promoting tissue repair, excessive or chronic IL-22 production can exacerbate inflammatory diseases, such as psoriasis, inflammatory bowel disease (IBD), and rheumatoid arthritis (RA). Its involvement in balancing tissue protection and inflammation highlights its significance in health and disease.
IL-22 is a monomeric glycoprotein composed of 146 amino acids, with a molecular weight of approximately 19.5 kDa. Structurally, IL-22 is part of the IL-10 cytokine family, which also includes IL-10, IL-24, IL-26, and IL-28/IL-29 (IFN-lambda). Like other cytokines in this family, IL-22 adopts a typical four-α-helix bundle structure.
IL-22 is classified as a member of the IL-10 family of cytokines, which are characterized by their ability to modulate immune responses and epithelial cell functions. Within the IL-22 cytokine family, no distinct subtypes of IL-22 exist, but it works in concert with other cytokines, such as IL-17 and IL-23, which share roles in mediating inflammation and tissue protection at epithelial barriers.
IL-22 also interacts with IL-22 binding protein (IL-22BP), a soluble receptor that can bind to IL-22, preventing it from signaling through its receptor. IL-22BP acts as a natural antagonist of IL-22 and plays a key role in regulating its activity in tissues.
IL-22 is a key player in maintaining epithelial integrity and supporting host defense at mucosal surfaces. Its effects are largely protective and regenerative, but in certain circumstances, IL-22 can contribute to pathological inflammation.
Epithelial Cell Protection and Regeneration:
Immune Defense:
Inflammation and Autoimmunity:
Tissue-Specific Effects:
IL-22 has been implicated in various diseases due to its dual role in tissue protection and inflammation. While it plays a protective role in tissue repair and pathogen defense, excessive or dysregulated IL-22 signaling can contribute to autoimmune diseases and chronic inflammatory conditions.
Psoriasis:
Inflammatory Bowel Disease (IBD):
Rheumatoid Arthritis (RA):
Liver Diseases:
IL-22 has emerged as a potential therapeutic target due to its role in autoimmune and inflammatory diseases. Therapies that modulate IL-22 activity could be beneficial for diseases like psoriasis, RA, and IBD. Additionally, given its role in promoting tissue regeneration, IL-22 is being explored for therapeutic applications in tissue repair and regeneration following injury.
IL-22 is a critical cytokine that modulates epithelial barrier integrity, antimicrobial defense, and tissue repair. Its dual nature—both protective and inflammatory—makes it a key player in immune responses at mucosal surfaces. While IL-22 supports tissue regeneration and protects against pathogens, dysregulated IL-22 activity contributes to chronic inflammation and autoimmune diseases. Understanding the context-specific roles of IL-22 is essential for developing targeted therapies that harness its regenerative properties while mitigating its pro-inflammatory effects.
interleukin 22 (IL22)
TIFa,IL-21,IL-22,ILTIF,IL-TIF,IL-D110,zcyto18,TIFIL-23,Cytokine Zcyto18,IL-10-related T-cell-derived-inducible factor IL-TIF,
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con IL22 - interleukin 22
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 48 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL22 | abx357061 | Chicken Interleukin 22 (IL22) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 662.5 | 96 tests | RUO | |
Abbexa | IL22 | abx150152 | Cow Interleukin 22 (IL22) ELISA Kit | Cow | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.6 pg/ml | 737.5 | 96 tests | A5JS75 | RUO |
Abbexa | IL22 | abx493396 | Cow Interleukin 22 (IL22) CLIA Kit | Cow | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 5.9 pg/ml | 868.75 | 96 tests | A5JS75 | RUO |
FineTest | IL22 | EH0191 | Human IL-22(Interleukin-22) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q9GZX6 | RUO | ||
Abbexa | IL22 | abx190316 | Human Interleukin 22 (IL22) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.64 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL22 | abx152030 | Human Interleukin 22 (IL22) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6 pg/ml | 687.5 | 96 tests | Q9GZX6 | RUO |
Abbexa | IL22 | abx251228 | Human Interleukin 22 (IL22) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 468.75 | 96 tests | RUO | |
Abbexa | IL22 | abx195887 | Human Interleukin 22 (IL-22) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | |
FineTest | IL22 | EM1810 | Mouse IL-22(Interleukin 22) ELISA Kit | mouse | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q9JJY9 | RUO | ||
Abbexa | IL22 | abx154246 | Mouse Interleukin 22 (IL22) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.7 pg/ml | 500 | 96 tests | Q9JJY9 | RUO |
Abbexa | IL22 | abx365160 | Low Sample Volume Mouse Interleukin 22 (IL22) ELISA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 15.63 pg/ml - 1000 pg/ml | 9.2 pg/ml | 437.5 | 96 tests | Q9JJY9 | RUO |
Abbexa | IL22 | abx190572 | Mouse Interleukin 22 (IL22) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.52 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL22 | abx353232 | Low Sample Volume Mouse Interleukin 22 (IL22) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.7 pg/ml | 550 | 96 tests | Q9JJY9 | RUO |
FineTest | IL22 | EP0178 | Porcine IL-22(Interleukin 22) ELISA Kit | porcine | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 46.875-3000pg/ml | 96T | Q58NA6 | RUO | ||
FineTest | IL22 | ER1630 | Rat IL-22(Interleukin 22) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q198B4 | RUO | ||
Abbexa | IL22 | abx354115 | Rat Interleukin 22 (IL22) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 493.75 | 96 tests | Q198B4 | RUO |
Abbexa | IL22 | abx585150 | Rat Interleukin 22 (IL22) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.3 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | IL22 | abx585573 | Sheep Interleukin 22 (IL22) ELISA Kit | Sheep | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.9 pg/ml | 743.75 | 96 tests | RUO | |
Abbexa | IL22 | abx364758 | Sheep Interleukin 22 (IL22) ELISA Kit | Sheep | Serum,Plasma,Other biological fluids | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 743.75 | 96 tests | H2AKX1 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL22 | abx037046 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | ELISA, WB | 337.5 | 100 µg | BC069308 | RUO | |
Abbexa | IL22 | abx128959 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q9GZX6 | RUO | |
Abbexa | IL22 | abx027751 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9GZX6 | RUO | |
Abbexa | IL22 | abx173135 | Interleukin 22 (IL22) Antibody | Human | Monoclonal | Mouse | Interleukin 22 (IL22) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | IL22 | abx320208 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q9GZX6 | RUO | |
Abbexa | IL22 | abx038102 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | IL22 | abx270285 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | IL22 | abx216205 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9GZX6 | RUO | |
Abbexa | IL22 | abx006813 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | WB, IF/ICC | 175 | 20 µl | Q9GZX6 | RUO | |
Abbexa | IL22 | abx113249 | Interleukin 22 (IL22) Antibody | Human | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9GZX6 | RUO | |
Abbexa | IL22 | abx129688 | Interleukin 22 (IL22) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 22 (IL22) | Unconjugated | WB, IHC, IF/ICC | 212.5 | 100 µl | Q9JJY9 | RUO | |
Abbexa | IL22 | abx412346 | Interleukin 22 (IL22) Antibody (Biotin) | Pig | Polyclonal | Rabbit | Interleukin 22 (IL22) | Biotin | ELISA, WB | 650 | 50 µg | F1SH68 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL22 | abx262190 | Rat Interleukin 22 (IL22) Protein | Rat | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | G3V6X6 | RUO | |
Abbexa | IL22 | abx694251 | Mouse Interleukin 22 (IL22) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | Q9JJY9 | RUO | |
Abbexa | IL22 | abx651527 | Human Interleukin 22 (IL22) Protein | Human | Recombinant | 293F cell | Unconjugated | WB, SDS-PAGE | 637.5 | 50 µg | Q9GZX6 | RUO |
Abbexa | IL22 | abx654012 | Cow Interleukin 22 (IL22) Protein | Cow | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2112.5 | 1 mg | RUO | |
Abbexa | IL22 | abx262260 | Mouse Interleukin 22 (IL22) Protein | Mouse | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9JJY9 | RUO | |
FineTest | IL22 | P6627 | Recombinant Human IL-22 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9GZX6 | RUO | ||
FineTest | IL22 | P5908 | Recombinant Rat IL-22 | Rat | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q198B4 | RUO | ||
Abbexa | IL22 | abx670220 | Human Interleukin 22 (IL22) Protein | Human | E. coli | Unconjugated | 450 | 10 µg | Q9GZX6 | RUO | ||
Abbexa | IL22 | abx262237 | Human Interleukin 22 (IL22) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9GZX6 | RUO | |
Abbexa | IL22 | abx167089 | Human Interleukin 22 (IL22) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9GZX6 | RUO |
FineTest | IL22 | P6731 | Recombinant Mouse IL-22 | Mouse | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q9JJY9 | RUO | ||
Abbexa | IL22 | abx694124 | Human Interleukin 22 (IL22) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 400 | 20 µg | Q9GZX6 | RUO | |
Abbexa | IL22 | abx263086 | Mouse Interleukin 22 (IL22) Protein | Mouse | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q9JJY9 | RUO | |
Abbexa | IL22 | abx670319 | Pig Interleukin 22 (IL22) Protein | Pig | Yeast | Unconjugated | ELISA, WB | 312.5 | 5 µg | F1SH68 | RUO | |
Abbexa | IL22 | abx655724 | Human Interleukin 22 (IL22) Protein (Active) | Human | Recombinant | Unconjugated | WB, SDS-PAGE | 650 | 50 µg | RUO | ||
Abbexa | IL22 | abx655723 | Human Interleukin 22 (IL22) Protein (Active) | Human | Recombinant | Unconjugated | WB, SDS-PAGE | 650 | 50 µg | RUO | ||
Abbexa | IL22 | abx167450 | Mouse Interleukin 22 (IL22) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9JJY9 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.