Family main features
Hepcidin, a peptide hormone primarily synthesized in the liver, plays a crucial role in regulating iron metabolism. It runs iron absorption in the intestine, release from macrophages, and transportation in the bloodstream by interacting with ferroportin, a protein responsible for exporting iron from cells. When hepcidin binds to ferroportin, it prompts internalization and degradation of ferroportin, ultimately reducing iron absorption and release into the bloodstream to maintain iron homeostasis. Various factors influence hepcidin synthesis and secretion, including iron stores, inflammation (as hepcidin is an acute phase reactant), hypoxia, and erythropoiesis. For instance, large iron stores induce the production of Bone Morphogenic Protein (BMP), which triggers hepcidin expression via the SMAD pathway. Inflammation stimulates hepcidin production by releasing interleukin-6, which activates the HAMP gene through the JAK/STAT pathway. Conversely, hypoxia suppresses hepcidin production through the action of hypoxia-inducible factor (HIF), which, under normal conditions, is degraded by von Hippel-Lindau (VHL) and prolyl dehydrogenase (PHD). Dysregulation of hepcidin levels can lead to disorders such as iron deficiency anemia or hereditary hemochromatosis.
Hepcidin is a small peptide hormone consisting of 25 amino acids in its mature form. It is initially synthesized as an 84-amino acid preprohepcidin, which undergoes proteolytic cleavage to produce prohepcidin (60 amino acids) and eventually the mature hepcidin-25. The structure of hepcidin is stabilized by four disulfide bonds, giving it a robust conformation essential for its biological activity.
There are three main forms of hepcidin found in human serum: hepcidin-25, hepcidin-22, and hepcidin-20. Hepcidin-25 is the biologically active form, while the shorter forms (hepcidin-22 and hepcidin-20) are considered to be degradation products with reduced or no biological activity.
Hepcidin, encoded by the HAMP gene, is a central regulator of iron metabolism, controlling iron absorption, distribution, and storage through its interaction with ferroportin. It plays a significant role in maintaining iron homeostasis and responding to inflammation. Dysregulation of hepcidin levels is implicated in various clinical conditions, including iron overload disorders, anemia of chronic disease, and iron deficiency anemia. Understanding hepcidin's function and regulation provides insights into therapeutic strategies for managing these iron-related disorders.
Hepcidin antimicrobial peptide (HAMP)
HEPC,PLTR,HFE2B,LEAP1,Putative liver tumor regressor,PLTR
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con HAMP - Hepcidin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 68 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | HAMP | abx150111 | Cow Hepcidin (HAMP) ELISA Kit | Cow | Serum,Plasma,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 11.7 pg/ml | 700 | 96 tests | RUO | |
Abbexa | HAMP | abx493325 | Cow Hepcidin (HAMP) CLIA Kit | Cow | Serum, plasma and other biological fluids. | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.214 ng/ml | 837.5 | 96 tests | RUO | |
Abbexa | HAMP | abx585144 | Dog Hepcidin (HAMP) ELISA Kit | Dog | Serum,Plasma,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.25 ng/ml | 687.5 | 96 tests | RUO | |
FineTest | HAMP | EH3221 | Human Hepc(Hepcidin) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | P81172 | RUO | ||
Abbexa | HAMP | abx190359 | Human Hepcidin (HAMP) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 5.49 pg/ml - 4000 pg/ml | < 1.89 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | HAMP | abx251355 | Human Hepcidin (HAMP) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 556.25 | 96 tests | RUO | |
Abbexa | HAMP | abx490446 | Human Hepcidin (HAMP) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Competitive | 78.13 pg/ml - 20000 pg/ml | < 27.74 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | HAMP | abx055139 | Human Hepcidin 25 (Hepc-25) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 587.5 | 96 tests | P81172 | RUO |
Abbexa | HAMP | abx151797 | Human Hepcidin (HAMP) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Competitive | 32 pg/ml - 20000 pg/ml | < 11 pg/ml | 662.5 | 96 tests | RUO | |
Abbexa | HAMP | abx252624 | Human Hepcidin 25 (Hepc-25) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | 0.94 ng/ml | 562.5 | 96 tests | P81172 | RUO |
Abbexa | HAMP | abx051456 | Human Hepcidin (HAMP) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | < 26.4 pg/ml | 725 | 96 tests | RUO | |
Abbexa | HAMP | abx251363 | Human Hepcidin Propeptide (HAMP) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | RUO | ||
Abbexa | HAMP | abx195730 | Human Hepcidin (HAMP) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | HAMP | abx359261 | Monkey Hepcidin (HAMP) ELISA Kit | Monkey | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 600 | 96 tests | RUO | |
FineTest | HAMP | EM1114 | Mouse Hepc(Hepcidin) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 3.125-200ng/ml | 96T | Q9EQ21 | RUO | ||
Abbexa | HAMP | abx156846 | Mouse Hepcidin (HAMP) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Competitive | 0.16 ng/ml - 100 ng/ml | < 0.06 ng/ml | 675 | 96 tests | RUO | |
Abbexa | HAMP | abx493326 | Mouse Hepcidin (HAMP) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 13.7 pg/ml - 10000 pg/ml | < 6 pg/ml | 868.75 | 96 tests | RUO | |
Abbexa | HAMP | abx490447 | Mouse Hepcidin (HAMP) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Competitive | 1.23 ng/ml - 100 ng/ml | < 0.52 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | HAMP | abx257710 | Mouse Hepcidin (HAMP) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 6.25 pg/ml - 400 pg/ml | 3.75 pg/ml | 493.75 | 96 tests | RUO | |
Abbexa | HAMP | abx051816 | Mouse Hepcidin (HAMP) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Competitive | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 712.5 | 96 tests | RUO | |
Abbexa | HAMP | abx254168 | Mouse Hepcidin (HAMP) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 125 pg/ml - 8000 pg/ml | 75 pg/ml | 556.25 | 96 tests | Q9EQ21 | RUO |
Abbexa | HAMP | abx154134 | Mouse Hepcidin (HAMP) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | < 25.2 pg/ml | 743.75 | 96 tests | RUO | |
Abbexa | HAMP | abx195741 | Mouse Hepcidin (HAMP) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | HAMP | abx490448 | Pig Hepcidin (HAMP) CLIA Kit | Pig | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Competitive | 740.74 pg/ml - 60000 pg/ml | < 283.51 pg/ml | 837.5 | 96 tests | RUO | |
Abbexa | HAMP | abx258196 | Pig Hepcidin (HAMP) ELISA Kit | Pig | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Competitive | 740.7 pg/ml - 60000 pg/ml | < 283.51 pg/ml | 700 | 96 tests | RUO | |
FineTest | HAMP | ER1036 | Rat Hepc(Hepcidin) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q99MH3 | RUO | ||
Abbexa | HAMP | abx055501 | Rat Hepcidin (HAMP) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 743.75 | 96 tests | RUO | |
Abbexa | HAMP | abx258015 | Rat Hepcidin (HAMP) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Competitive | 1.23 ng/ml - 100 ng/ml | < 0.45 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | HAMP | abx490449 | Rat Hepcidin (HAMP) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Competitive | 390.6 pg/ml - 100000 pg/ml | < 158 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | HAMP | abx256595 | Rat Hepcidin (HAMP) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 556.25 | 96 tests | Q99MH3 | RUO |
Abbexa | HAMP | abx195742 | Rat Hepcidin (HAMP) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | HAMP | abx176832 | Hepcidin (HAMP) Antibody | Cow | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 312.5 | 100 µl | RUO | ||
Abbexa | HAMP | abx172793 | Hepcidin (HAMP) Antibody | Cow | Monoclonal | Mouse | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 900 | 1 ml | RUO | ||
Abbexa | HAMP | abx104812 | Hepcidin (HAMP) Antibody | Cow | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q2NKT0 | RUO | |
Abbexa | HAMP | abx176831 | Hepcidin (HAMP) Antibody | Cow | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 312.5 | 100 µl | RUO | ||
Abbexa | HAMP | abx176829 | Hepcidin (HAMP) Antibody | Human | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P81172 | RUO | |
Abbexa | HAMP | abx176827 | Hepcidin (HAMP) Antibody | Human | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P81172 | RUO | |
Abbexa | HAMP | abx215857 | Hepcidin Propeptide (HAMP) Antibody | Human | Polyclonal | Rabbit | Hepcidin Propeptide (HAMP) | Unconjugated | ELISA | 350 | 100 µg | P81172 | RUO | |
Abbexa | HAMP | abx131894 | Hepcidin (HAMP) Antibody | Human | Monoclonal | Mouse | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P81172 | RUO | |
Abbexa | HAMP | abx378018 | Hepcidin (Hepc) Antibody Pair | Human | Hepcidin (Hepc) | ELISA | 525 | 5 × 96 tests | P81172 | RUO | ||||
Abbexa | HAMP | abx100264 | Hepcidin (HAMP) Antibody | Human | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P81172 | RUO | |
Abbexa | HAMP | abx272224 | Hepcidin (HAMP) Antibody (Biotin) | Human | Polyclonal | Rabbit | Hepcidin (HAMP) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | HAMP | abx432782 | Hepcidin (HAMP) Antibody | Human | Polyclonal | Goat | Hepcidin (HAMP) | Unconjugated | P-ELISA, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | HAMP | abx273664 | Hepcidin (HAMP) Antibody (FITC) | Human | Polyclonal | Rabbit | Hepcidin (HAMP) | FITC | WB, IHC, IF/ICC | 412.5 | 200 µl | RUO | ||
Abbexa | HAMP | abx001348 | Hepcidin (HAMP) Antibody | Human | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB | 175 | 20 µl | P81172 | RUO | |
Abbexa | HAMP | abx100265 | Hepcidin (HAMP) Antibody | Mouse | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9EQ21 | RUO | |
Abbexa | HAMP | abx273905 | Hepcidin (HAMP) Antibody (FITC) | Mouse | Polyclonal | Rabbit | Hepcidin (HAMP) | FITC | WB, IHC, IF/ICC | 425 | 200 µl | RUO | ||
Abbexa | HAMP | abx272813 | Hepcidin (HAMP) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Hepcidin (HAMP) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | HAMP | abx100267 | Hepcidin (HAMP) Antibody | Pig | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q8MJ80 | RUO | |
Abbexa | HAMP | abx172794 | Hepcidin (HAMP) Antibody | Pig | Monoclonal | Mouse | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 900 | 1 ml | RUO | ||
Abbexa | HAMP | abx100266 | Hepcidin (HAMP) Antibody | Rat | Polyclonal | Rabbit | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q99MH3 | RUO | |
Abbexa | HAMP | abx172792 | Hepcidin (HAMP) Antibody | Rat | Monoclonal | Mouse | Hepcidin (HAMP) | Unconjugated | WB, IHC, IF/ICC | 812.5 | 1 ml | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | HAMP | abx651223 | Human Hepcidin 25 (Hepc-25) Peptide (OVA) | Human | Synthetic | OVA | WB, SDS-PAGE | 425 | 100 µg | P81172 | RUO | |
Abbexa | HAMP | abx651222 | Human Hepcidin 25 (Hepc-25) Peptide (OVA) | Human | Synthetic | OVA | SDS-PAGE | 425 | 100 µg | P81172 | RUO | |
FineTest | HAMP | P1603 | Recombinant Mouse Hepc | Mouse | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q9EQ21 | RUO | ||
Abbexa | HAMP | abx651855 | Cow Hepcidin (HAMP) Peptide (BSA) | Cow | Synthetic | BSA | WB, SDS-PAGE | 475 | 100 µg | Q2NKT0 | RUO | |
Abbexa | HAMP | abx067077 | Human Hepcidin (HAMP) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P81172 | RUO |
Abbexa | HAMP | abx067078 | Mouse Hepcidin (HAMP) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9EQ21 | RUO |
Abbexa | HAMP | abx067079 | Pig Hepcidin (HAMP) Protein | Pig | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 387.5 | 50 µg | Q8MJ80 | RUO |
Abbexa | HAMP | abx651497 | Human Hepcidin (HAMP) Protein | Human | Recombinant | 293F cell | Unconjugated | WB, SDS-PAGE | 587.5 | 50 µg | P81172 | RUO |
FineTest | HAMP | P1773 | Recombinant Human Hepc | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P81172 | RUO | ||
Abbexa | HAMP | abx651221 | Human Hepcidin Propeptide (HAMP) Peptide (OVA) | Human | Synthetic | OVA | WB, SDS-PAGE | 425 | 100 µg | P81172 | RUO | |
Abbexa | HAMP | abx166315 | Cow Hepcidin (HAMP) Protein | Cow | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 437.5 | 50 µg | RUO | |
Abbexa | HAMP | abx655669 | Human Hepcidin (HAMP) Protein (Active) | Human | Recombinant | 293F cell | Unconjugated | WB, SDS-PAGE | 375 | 50 µg | P81172 | RUO |
FineTest | HAMP | P1510 | Recombinant rat Hepc | Rat | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q99MH3 | RUO | ||
Abbexa | HAMP | abx067080 | Rat Hepcidin Precursor (HAMP) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q99MH3 | RUO |
Abbexa | HAMP | abx651220 | Cow Hepcidin (HAMP) Peptide (OVA) | Cow | Synthetic | OVA | WB, SDS-PAGE | 425 | 100 µg | Q2NKT0 | RUO | |
Abbexa | HAMP | abx651219 | Cow Hepcidin (HAMP) Peptide (OVA) | Cow | Synthetic | OVA | WB, SDS-PAGE | 425 | 100 µg | Q2NKT0 | RUO |
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