Human Hepcidin 25 (Hepc-25) ELISA Kit
611€ (96 tests)
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935106861
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name
Human Hepcidin 25 (Hepc-25) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx055139
tested applications
ELISA
Description
Human Hepcidin 25 (Hepc-25) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Hepcidin 25 (Hepc-25) concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Hepcidin 25 (Hepc-25) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | 9.38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P81172 |
| Alias | HEPC,PLTR,HFE2B,LEAP1,Putative liver tumor regressor,PLTR |
| Background | Elisa kits for HAMP |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Hepcidin Antimicrobial Peptide (HAMP) is a small, liver-derived peptide hormone that serves as the master regulator of systemic iron homeostasis and possesses antimicrobial properties. Hepcidin controls iron levels by binding to the iron export protein ferroportin, leading to its internalization and degradation, thereby reducing iron release from enterocytes, macrophages, and hepatocytes into the bloodstream. This regulation is critical for preventing iron overload and ensuring adequate iron availability for erythropoiesis. HAMP expression is modulated by factors such as systemic iron levels, inflammation, erythropoietic demand, and hypoxia. Inflammatory cytokines, particularly IL-6, stimulate HAMP production via the JAK-STAT pathway, contributing to the anemia of chronic disease by sequestering iron in storage sites. Conversely, inadequate HAMP expression leads to conditions such as hereditary hemochromatosis and iron-loading anemias. In addition to its role in iron metabolism, HAMP exhibits antimicrobial activity by directly targeting bacterial pathogens, making it a key component of the innate immune response. Therapeutic manipulation of HAMP is being explored for treating iron disorders and related conditions.
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