Human Hepcidin (HAMP) Protein
221€ (10 µg)
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name
Human Hepcidin (HAMP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067077
tested applications
WB, SDS-PAGE
Description
Recombinant Hepcidin (HAMP) is a recombinant Human protein. It isproduced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Hepcidin (HAMP) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 12.6 kDa Observed MW (SDS-PAGE): 16 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser25-Thr84 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P81172 |
| Gene ID | 57817 |
| Alias | HEPC,PLTR,HFE2B,LEAP1,Putative liver tumor regressor,PLTR |
| Background | Protein HAMP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Hepcidin Antimicrobial Peptide (HAMP) is a small, liver-derived peptide hormone that serves as the master regulator of systemic iron homeostasis and possesses antimicrobial properties. Hepcidin controls iron levels by binding to the iron export protein ferroportin, leading to its internalization and degradation, thereby reducing iron release from enterocytes, macrophages, and hepatocytes into the bloodstream. This regulation is critical for preventing iron overload and ensuring adequate iron availability for erythropoiesis. HAMP expression is modulated by factors such as systemic iron levels, inflammation, erythropoietic demand, and hypoxia. Inflammatory cytokines, particularly IL-6, stimulate HAMP production via the JAK-STAT pathway, contributing to the anemia of chronic disease by sequestering iron in storage sites. Conversely, inadequate HAMP expression leads to conditions such as hereditary hemochromatosis and iron-loading anemias. In addition to its role in iron metabolism, HAMP exhibits antimicrobial activity by directly targeting bacterial pathogens, making it a key component of the innate immune response. Therapeutic manipulation of HAMP is being explored for treating iron disorders and related conditions.
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