Hepcidin (HAMP) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Hepcidin (HAMP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131894
Description
Hepcidin (HAMP) Antibody is a Mouse Monoclonal against Hepcidin (HAMP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Hepcidin (HAMP) Immunogen: abx067077 - Recombinant HAMP (Ser25-Thr84) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b Kappa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P81172 |
| Gene ID | 57817 |
| Alias | HEPC,PLTR,HFE2B,LEAP1,Putative liver tumor regressor,PLTR |
| Background | Antibody anti-HAMP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Hepcidin Antimicrobial Peptide (HAMP) is a small, liver-derived peptide hormone that serves as the master regulator of systemic iron homeostasis and possesses antimicrobial properties. Hepcidin controls iron levels by binding to the iron export protein ferroportin, leading to its internalization and degradation, thereby reducing iron release from enterocytes, macrophages, and hepatocytes into the bloodstream. This regulation is critical for preventing iron overload and ensuring adequate iron availability for erythropoiesis. HAMP expression is modulated by factors such as systemic iron levels, inflammation, erythropoietic demand, and hypoxia. Inflammatory cytokines, particularly IL-6, stimulate HAMP production via the JAK-STAT pathway, contributing to the anemia of chronic disease by sequestering iron in storage sites. Conversely, inadequate HAMP expression leads to conditions such as hereditary hemochromatosis and iron-loading anemias. In addition to its role in iron metabolism, HAMP exhibits antimicrobial activity by directly targeting bacterial pathogens, making it a key component of the innate immune response. Therapeutic manipulation of HAMP is being explored for treating iron disorders and related conditions.
Related Products
Human Hepcidin (HAMP) Protein
Human Hepcidin (HAMP) is a recombinant Human protein. It isexpressed in E. coli.
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