Family main features
Hemicentins are a group of extracellular matrix (ECM) proteins that are highly conserved across species, including humans. The human hemicentin family includes two primary members: HMCN1 and HMCN2. These proteins are essential for various cellular processes, including maintaining tissue integrity and facilitating cell-matrix and cell-cell interactions. Hemicentins were initially identified in Caenorhabditis elegans, where they play critical roles in the structural integrity of tissues, particularly in maintaining the stability of the basement membrane.
Hemicentins are large, multidomain proteins with complex structures that are key to their function in the extracellular matrix. The primary structure of hemicentin includes several distinct domains:
The combination of these domains allows hemicentins to interact with a variety of ECM components and cell surface receptors, contributing to their multifaceted roles in tissue maintenance and cellular functions.
Hemicentins belong to a larger family of ECM proteins that share structural similarities and functional properties. The primary members of the hemicentin family in humans are:
Hemicentins are crucial for several biological processes:
Alterations in hemicentin expression or function are associated with several clinical conditions:
Hemicentins are essential ECM proteins that play critical roles in maintaining tissue integrity, facilitating cell adhesion, and regulating cell migration. Their complex structure, comprising Ig domains, FN3 domains, EGF-like domains, TSP repeats, and coiled-coil regions, enables their multifunctional capabilities. Hemicentins are involved in developmental processes, tissue repair, and remodeling, and their dysregulation is linked to various clinical conditions, including macular degeneration, cancer, neurological disorders, and skin diseases. Understanding the molecular mechanisms of hemicentin function and their role in health and disease could lead to novel therapeutic approaches for these conditions.
hemicentin 1 (HMCN1)
ARMD1,FBLN6,FIBL6,FIBL-6,Fibulin-6
hemicentin 2 (HMCN2)
Hemicentin-2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con HMCN - hemicentin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 7 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | HMCN1 | abx387823 | Human Hemicentin 1 (HMCN1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | Q96RW7 | RUO |
Abbexa | HMCN2 | abx527201 | Human Hemicentin-2 (HMCN2) ELISA Kit | Human | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | < 0.072 | 687.5 | 96 tests | Q8NDA2 | RUO | |
Abbexa | HMCN1 | abx258002 | Mouse Hemicentin 1 (HMCN1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | HMCN1 | abx493747 | Mouse Hemicentin 1 (HMCN1) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.058 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | HMCN2 | abx527202 | Mouse Hemicentin-2 (HMCN2) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | 78 pg/ml - 5000 pg/ml | < 31 pg/ml | 687.5 | 96 tests | A2AJ76 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | HMCN1 | abx129890 | Hemicentin 1 (HMCN1) Antibody | Mouse | Polyclonal | Rabbit | Hemicentin 1 (HMCN1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | HMCN1 | abx168363 | Mouse Hemicentin 1 (HMCN1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.