Mouse Hemicentin 1 (HMCN1) Protein

Este producto es parte de HMCN - hemicentin
Product Graph
234€ (10 µg)

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935106861
info@markelab.com
name
Mouse Hemicentin 1 (HMCN1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168363
tested applications
WB, SDS-PAGE

Description

Hemicentin 1 Protein is a recombinant protein produced in Mouse.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Hemicentin 1 (HMCN1)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 18.4 kDa  Observed MW: 18 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Gly22-Val153
Tag: N-terminal His tag and GST tag
Expression
Recombinant
Purity
> 92%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
ARMD1,FBLN6,FIBL6,FIBL-6,Fibulin-6
Background
Protein HMCN1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Hemicentin 1 (HMCN1) is a large extracellular matrix protein that belongs to the fibulin family and is characterized by its multiple immunoglobulin (Ig)-like and epidermal growth factor (EGF)-like domains. It is primarily involved in the maintenance of tissue architecture and cell adhesion processes. HMCN1 is widely expressed in tissues such as the eyes, skin, and kidneys, where it contributes to basement membrane stability and the organization of extracellular structures. Mutations in the HMCN1 gene have been associated with age-related macular degeneration (AMD), suggesting a critical role in retinal integrity and function. In addition, HMCN1 is implicated in cancer biology, where its dysregulation has been linked to altered tumor microenvironments and metastatic potential. The protein’s interactions with integrins and other ECM components underline its importance in cell signaling and tissue homeostasis, making it a significant focus in studies on tissue repair, fibrosis, and oncogenesis.

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