Hemicentin 1 (HMCN1) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Hemicentin 1 (HMCN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx129890
tested applications
WB, IHC, IF/ICC
Description
Hemicentin 1 Antibody is a Rabbit Polyclonal against Hemicentin 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Hemicentin 1 (HMCN1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ARMD1,FBLN6,FIBL6,FIBL-6,Fibulin-6 |
| Background | Antibody anti-HMCN1 |
| Status | RUO |
| Note | Concentration: 0.34 mg/ml - |
Descripción
Hemicentin 1 (HMCN1) is a large extracellular matrix protein that belongs to the fibulin family and is characterized by its multiple immunoglobulin (Ig)-like and epidermal growth factor (EGF)-like domains. It is primarily involved in the maintenance of tissue architecture and cell adhesion processes. HMCN1 is widely expressed in tissues such as the eyes, skin, and kidneys, where it contributes to basement membrane stability and the organization of extracellular structures. Mutations in the HMCN1 gene have been associated with age-related macular degeneration (AMD), suggesting a critical role in retinal integrity and function. In addition, HMCN1 is implicated in cancer biology, where its dysregulation has been linked to altered tumor microenvironments and metastatic potential. The protein’s interactions with integrins and other ECM components underline its importance in cell signaling and tissue homeostasis, making it a significant focus in studies on tissue repair, fibrosis, and oncogenesis.
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