Family main features
Toll-like receptor 8 (TLR8) is a member of the toll-like receptor family, which plays a crucial role in the innate immune system by recognizing specific molecular patterns associated with pathogens. TLR8, in particular, is an endosomal receptor that primarily recognizes single-stranded RNA (ssRNA) from viruses and other microorganisms, making it a significant player in detecting RNA viruses, such as influenza and certain coronaviruses. As part of the pattern recognition receptor (PRR) family, TLR8 is instrumental in initiating the innate immune response upon detection of foreign RNA, leading to the production of inflammatory cytokines and antiviral responses.
TLR8 expression is largely found within immune cells, specifically in monocytes, macrophages, and dendritic cells, with notable expression in myeloid dendritic cells. Its activation is associated with the MyD88-dependent signaling pathway, which ultimately results in the production of cytokines and type I interferons (IFNs), essential mediators in controlling viral infections. TLR8’s unique role in recognizing RNA-based pathogens positions it as a potential therapeutic target for treating viral infections, certain inflammatory diseases, and possibly cancers.
TLR8 is a type I transmembrane protein and shares a highly conserved structural framework with other toll-like receptors. It consists of approximately 1,040 amino acids organized into three primary domains: an extracellular domain, a transmembrane domain, and a cytoplasmic Toll/interleukin-1 receptor (TIR) domain. These domains allow TLR8 to recognize ligands, transduce signals, and initiate downstream signaling cascades effectively.
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic TIR Domain:
TLR8 is part of the TLR7/8/9 subfamily within the toll-like receptor family, which includes receptors that recognize nucleic acids and are located in endosomal compartments. It is closely related to TLR7, which also detects RNA ligands, though each has specific ligand preferences and expression profiles.
There are no distinct subtypes or isoforms of TLR8, though its expression and function may vary depending on the cell type and the inflammatory environment. While TLR7 is more commonly expressed in plasmacytoid dendritic cells, TLR8 is primarily expressed in myeloid cells, such as macrophages and conventional dendritic cells, contributing to distinct yet complementary roles in pathogen recognition and immune activation.
TLR8 plays an essential role in the immune response by detecting single-stranded RNA from pathogens and initiating an antiviral immune response. Key functions of TLR8 include:
Pathogen Detection:
Immune Activation and Inflammatory Signaling:
Role in Adaptive Immunity:
Self-RNA Recognition and Autoimmunity:
Dysregulation of TLR8 signaling is associated with various inflammatory and autoimmune diseases, viral infections, and cancers:
Autoimmune Diseases:
Viral Infections:
Cancer:
Therapeutic Targeting:
TLR8 is a critical toll-like receptor that plays a vital role in detecting single-stranded RNA from pathogens, particularly RNA viruses, within the endosome of immune cells. Its structure, which includes an LRR-rich extracellular domain and a TIR domain for intracellular signaling, enables it to recognize viral RNA directly and initiate a potent immune response via the MyD88-dependent pathway. This response includes cytokine production and the activation of NF-κB and IRF7, which promote antiviral immunity and inflammation.
Clinically, TLR8 is involved in a range of inflammatory diseases, autoimmune conditions, and cancers. While it provides essential antiviral defenses, excessive or inappropriate activation of TLR8 can contribute to autoimmune diseases like SLE and RA. In cancer, TLR8 signaling can either promote or inhibit tumor progression depending on the context, making it a promising yet complex therapeutic target. Therapeutics aimed at modulating TLR8 activity, including agonists for boosting immunity in infections and cancers, and antagonists for reducing inflammation in autoimmune diseases, continue to be explored for their potential benefits.
toll like receptor 8 (TLR8)
Toll-like receptor 8,CD288,IMD98,TLR-8,hTLR8
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con TLR8 - toll like receptor 8
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | TLR8 | EH4931 | Human TLR8(Toll-like receptor 8) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9NR97 | RUO | ||
Abbexa | TLR8 | abx153348 | Human Toll Like Receptor 8 (TLR8) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR8 | abx493342 | Human Toll Like Receptor 8 (TLR8) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.108 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR8 | abx519063 | Mouse Toll Like Receptor 8 (TLR8) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.18 ng/ml | 687.5 | 96 tests | P58682 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TLR8 | FNab10155 | anti- TLR8 antibody | human | polyclonal | Rabbit | Toll-like receptor 8 | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | Q9NR97 | RUO | |
Abbexa | TLR8 | abx027737 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx270123 | Toll Like Receptor 8 (TLR8) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 8 (TLR8) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | TLR8 | abx273659 | Toll Like Receptor 8 (TLR8) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | FITC | WB, IHC, IF/ICC | 412.5 | 200 µl | RUO | ||
Abbexa | TLR8 | abx210590 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx131785 | Toll Like Receptor 8 (TLR8) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 8 (TLR8) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx270885 | Toll Like Receptor 8 (TLR8) Antibody (PE) | Human | Monoclonal | Mouse | Toll Like Receptor 8 (TLR8) | PE | FCM | 575 | 100 tests | RUO | ||
Abbexa | TLR8 | abx270421 | Toll Like Receptor 8 (TLR8) Antibody (FITC) | Human | Monoclonal | Mouse | Toll Like Receptor 8 (TLR8) | FITC | FCM | 475 | 100 tests | RUO | ||
Abbexa | TLR8 | abx122862 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | TLR8 | abx270653 | Toll Like Receptor 8 (TLR8) Antibody (APC) | Human | Monoclonal | Mouse | Toll Like Receptor 8 (TLR8) | APC | FCM | 662.5 | 100 tests | RUO | ||
Abbexa | TLR8 | abx412581 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | WB | 437.5 | 100 µg | Q9NR97 | RUO | |
Abbexa | TLR8 | abx339872 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx174845 | Toll Like Receptor 8 (TLR8) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 8 (TLR8) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TLR8 | abx102077 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx272231 | Toll Like Receptor 8 (TLR8) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | TLR8 | abx212688 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx212942 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx001263 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx326825 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | Q9NR97 | RUO | |
Abbexa | TLR8 | abx117098 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | Q9NR97 | RUO | |
Abbexa | TLR8 | abx149074 | Toll Like Receptor 8 (TLR8) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q9NR97 | RUO | |
Abbexa | TLR8 | abx028486 | Mouse TLR8 Antibody | Mouse | Polyclonal | Rabbit | Mouse TLR8 | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P58682 | RUO | |
Abbexa | TLR8 | abx130075 | Toll Like Receptor 8 (TLR8) Antibody | Rat | Polyclonal | Rabbit | Toll Like Receptor 8 (TLR8) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR8 | abx600063 | Human Toll Like Receptor 8 (TLR8) Protein | Human | Recombinant | Yeast | SDS-PAGE | 337.5 | 20 µg | Q9NR97 | RUO | |
Abbexa | TLR8 | abx167615 | Rat Toll Like Receptor 8 (TLR8) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | TLR8 | abx069374 | Human Toll Like Receptor 8 (TLR8) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q9NR97 | RUO |
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