Toll Like Receptor 8 (TLR8) Antibody

Descripción

TLR8 Antibody is a Rabbit Polyclonal antibody against TLR8. The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunityThe TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductionsTLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domainThree TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressedTLR7 is expressed in lung, placenta and spleenTLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytesTLR7, TLR8 and TLR9 stimulate the NF˚B signaling pathway, suggesting that they play a role in the immune responseThis protein is involved in Immunology.