Human Toll Like Receptor 8 (TLR8) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Toll Like Receptor 8 (TLR8) Protein is a Human recombinant protein produced in Yeast.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Human Toll Like Receptor 8 (TLR8) |
| Host | Yeast |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 93.5 kDa Observed MW (SDS-PAGE): 93 kDa Sequence Fragment: 27-827 AA. Tag: N-terminal 6 His tag Validity: 6 months in liquid form, or 12 months in lyophilized form. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Affinity purified using IMAC. |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in deionized sterile water to a concentration of 0.1-1.0 mg/ml. It is recommended to add glycerol to a final glycerol concentration of 5-50%. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20°C and -80°C. After reconstitution, store between 2°C and 8°C for up to one week. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NR97 |
| Gene ID | 51311 |
| NCBI Accession | NP_057694.2 |
| OMIM | 300366 |
| Alias | Toll-like receptor 8,CD288,IMD98,TLR-8,hTLR8 |
| Background | Protein TLR8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Toll-like receptor 8 (TLR8) is a member of the toll-like receptor family, which plays a crucial role in the innate immune system by recognizing specific molecular patterns associated with pathogens. TLR8, in particular, is an endosomal receptor that primarily recognizes single-stranded RNA (ssRNA) from viruses and other microorganisms, making it a significant player in detecting RNA viruses, such as influenza and certain coronaviruses. As part of the pattern recognition receptor (PRR) family, TLR8 is instrumental in initiating the innate immune response upon detection of foreign RNA, leading to the production of inflammatory cytokines and antiviral responses. TLR8 expression is largely found within immune cells, specifically in monocytes, macrophages, and dendritic cells, with notable expression in myeloid dendritic cells. Its activation is associated with the MyD88-dependent signaling pathway, which ultimately results in the production of cytokines and type I interferons (IFNs), essential mediators in controlling viral infections. TLR8’s unique role in recognizing RNA-based pathogens positions it as a potential therapeutic target for treating viral infections, certain inflammatory diseases, and possibly cancers.
Related Products
Human TLR8 (Toll-like receptor 8) ELISA Kit
Ver Producto
TLR8 antibody
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Ver Producto