Toll Like Receptor 8 (TLR8) Antibody (Biotin)
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Description
Toll Like Receptor 8 (TLR8) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Toll Like Receptor 8 (TLR8).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Toll Like Receptor 8 (TLR8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Toll-like receptor 8,CD288,IMD98,TLR-8,hTLR8 |
| Background | Antibody anti-TLR8 |
| Status | RUO |
Descripción
Toll-like receptor 8 (TLR8) is a member of the toll-like receptor family, which plays a crucial role in the innate immune system by recognizing specific molecular patterns associated with pathogens. TLR8, in particular, is an endosomal receptor that primarily recognizes single-stranded RNA (ssRNA) from viruses and other microorganisms, making it a significant player in detecting RNA viruses, such as influenza and certain coronaviruses. As part of the pattern recognition receptor (PRR) family, TLR8 is instrumental in initiating the innate immune response upon detection of foreign RNA, leading to the production of inflammatory cytokines and antiviral responses. TLR8 expression is largely found within immune cells, specifically in monocytes, macrophages, and dendritic cells, with notable expression in myeloid dendritic cells. Its activation is associated with the MyD88-dependent signaling pathway, which ultimately results in the production of cytokines and type I interferons (IFNs), essential mediators in controlling viral infections. TLR8’s unique role in recognizing RNA-based pathogens positions it as a potential therapeutic target for treating viral infections, certain inflammatory diseases, and possibly cancers.
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
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