Family main features
Toll-like receptor 3 (TLR3) is a crucial component of the innate immune system and plays a significant role in the detection of viral double-stranded RNA (dsRNA), a molecular pattern associated with viral infections. Unlike other TLRs, TLR3 is predominantly responsible for recognizing viral RNA rather than bacterial or fungal components, making it particularly important in antiviral immunity. TLR3 is expressed not only in immune cells like macrophages and dendritic cells but also in non-immune cells, such as epithelial cells and fibroblasts, which are often the first to encounter viral pathogens. Upon detecting dsRNA, TLR3 activates pathways leading to type I interferon production and pro-inflammatory cytokine release, which are essential for controlling viral infections and coordinating subsequent adaptive immune responses.
TLR3 is primarily located in the endosomal membranes within cells, allowing it to recognize viral RNA that enters cells through phagocytosis or endocytosis. Its role in initiating antiviral responses makes it a subject of interest for immunological research and therapeutic interventions, particularly in viral diseases, immune disorders, and even cancer. TLR3 signaling pathways and its effects on cell function have also highlighted its involvement in other disease processes, where aberrant TLR3 activation may contribute to inflammation and tissue damage. Its unique function in antiviral immunity and role in a broader range of diseases positions TLR3 as a promising target for therapeutic modulation.
TLR3 is a type I transmembrane protein composed of approximately 904 amino acids. It has a distinct structural composition, including an extracellular domain, a transmembrane region, and a cytoplasmic Toll/interleukin-1 receptor (TIR) domain:
Extracellular Domain:
Transmembrane Domain:
Intracellular (TIR) Domain:
TLR3 is classified as a member of the Toll-like receptor family, specifically involved in recognizing nucleic acids, particularly RNA. Unlike other TLRs that may recognize various bacterial and viral components, TLR3’s specificity is largely confined to viral dsRNA. It does not form heterodimers with other TLRs, differentiating it from receptors like TLR2, which requires dimerization partners for ligand recognition.
Recognition of Viral dsRNA:
Signal Transduction and Immune Response Activation:
Role in Antiviral Immunity:
Role in Non-viral Pathologies:
TLR3’s involvement in immune responses extends to various clinical conditions, including:
Viral Infections:
Autoimmune and Inflammatory Diseases:
Cancer:
Therapeutic Targeting:
TLR3 is a critical component of the innate immune system, primarily responsible for detecting viral dsRNA and initiating antiviral responses. Its structure, including leucine-rich repeats, a transmembrane domain, and a TIR domain, allows it to detect viral RNA within endosomal compartments and signal through the TRIF pathway. This signaling cascade leads to the production of type I interferons and pro-inflammatory cytokines, essential for controlling viral replication and recruiting immune cells to infection sites.
The clinical relevance of TLR3 extends beyond viral immunity, as it has implications in autoimmune diseases, chronic inflammation, and cancer. TLR3 polymorphisms are associated with susceptibility to viral infections and autoimmune disorders, indicating that TLR3 function can influence disease outcomes. Therapeutic strategies targeting TLR3 include TLR3 agonists for antiviral and cancer therapies and inhibitors for autoimmune and inflammatory conditions.
Overall, TLR3 is an indispensable receptor in antiviral defense and immune modulation, making it a promising target for therapeutic interventions across a spectrum of infectious, inflammatory, and malignant diseases.
toll like receptor 3 (TLR3)
Toll-like receptor 3,CD283,IIAE2,IMD83,
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con TLR3 - toll like receptor 3
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Esta página contiene 43 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | TLR3 | abx519057 | Cow Toll Like Receptor 3 (TLR3) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5TJ59 | RUO | ||
FineTest | TLR3 | EH0301 | Human TLR3(Toll-like receptor 3) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O15455 | RUO | ||
Abbexa | TLR3 | abx493340 | Human Toll Like Receptor 3 (TLR3) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.055 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR3 | abx153343 | Human Toll Like Receptor 3 (TLR3) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR3 | abx190582 | Mouse Toll Like Receptor 3 (TLR3) CLIA Kit | Mouse | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 5.49 pg/ml - 4000 pg/ml | < 1.93 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR3 | abx154785 | Mouse Toll Like Receptor 3 (TLR3) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TLR3 | FNab08726 | anti- TLR3 antibody | human | polyclonal | Rabbit | toll-like receptor 3 | IgG | Unconjugated | ELISA, IHC | 100µg | O15455 | RUO | |
Abbexa | TLR3 | abx272229 | Toll Like Receptor 3 (TLR3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | TLR3 | abx339867 | Toll Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | ELISA, IHC | 250 | 50 µl | O15455 | RUO | |
Abbexa | TLR3 | abx174840 | Toll Like Receptor 3 (TLR3) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TLR3 | abx411792 | Toll-Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Unconjugated | WB, IHC | 462.5 | 100 µg | O15455 | RUO | |
Abbexa | TLR3 | abx339866 | Toll Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | ELISA, IHC | 250 | 50 µl | O15455 | RUO | |
Abbexa | TLR3 | abx270118 | Toll Like Receptor 3 (TLR3) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 3 (TLR3) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | TLR3 | abx270648 | Toll Like Receptor 3 (TLR3) Antibody (APC) | Human | Monoclonal | Mouse | Toll Like Receptor 3 (TLR3) | APC | FCM | 662.5 | 100 tests | RUO | ||
Abbexa | TLR3 | abx302127 | Toll-Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | O15455 | RUO | |
Abbexa | TLR3 | abx273661 | Toll Like Receptor 3 (TLR3) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | FITC | WB, IHC, IF/ICC | 412.5 | 200 µl | RUO | ||
Abbexa | TLR3 | abx270880 | Toll Like Receptor 3 (TLR3) Antibody (PE) | Human | Monoclonal | Mouse | Toll Like Receptor 3 (TLR3) | PE | FCM | 575 | 100 tests | RUO | ||
Abbexa | TLR3 | abx314369 | Toll-Like Receptor 3 (TLR3) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | FITC | 162.5 | 20 µg | O15455 | RUO | ||
Abbexa | TLR3 | abx102063 | Toll Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O15455 | RUO | |
Abbexa | TLR3 | abx270416 | Toll Like Receptor 3 (TLR3) Antibody (FITC) | Human | Monoclonal | Mouse | Toll Like Receptor 3 (TLR3) | FITC | FCM | 475 | 100 tests | RUO | ||
Abbexa | TLR3 | abx314370 | Toll-Like Receptor 3 (TLR3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Biotin | ELISA | 162.5 | 20 µg | O15455 | RUO | |
Abbexa | TLR3 | abx131783 | Toll Like Receptor 3 (TLR3) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 212.5 | 100 µl | O15455 | RUO | |
Abbexa | TLR3 | abx314368 | Toll-Like Receptor 3 (TLR3) Antibody (HRP) | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | HRP | ELISA | 162.5 | 20 µg | O15455 | RUO | |
Abbexa | TLR3 | abx213363 | Toll Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O15455 | RUO | |
Abbexa | TLR3 | abx028481 | Toll-Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | O15455 | RUO | |
Abbexa | TLR3 | abx213506 | Toll Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | ELISA, WB | 250 | 50 µl | O15455 | RUO | |
Abbexa | TLR3 | abx126709 | Toll-Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | O15455 | RUO | |
Abbexa | TLR3 | abx117094 | Toll-Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | O15455 | RUO | |
Abbexa | TLR3 | abx238726 | Toll-Like Receptor 3 (TLR3) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 3 (TLR3) | Unconjugated | ELISA, IHC | 350 | 100 µg | O15455 | RUO | |
Abbexa | TLR3 | abx272995 | Toll Like Receptor 3 (TLR3) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | TLR3 | abx370372 | Toll Like Receptor 3 (TLR3) Antibody Pair | Mouse | Toll Like Receptor 3 (TLR3) | ELISA | 1437.5 | 5 × 96 tests | RUO | |||||
Abbexa | TLR3 | abx102066 | Toll Like Receptor 3 (TLR3) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q99MB1 | RUO | |
Abbexa | TLR3 | abx102064 | Toll Like Receptor 3 (TLR3) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q99MB1 | RUO | |
Abbexa | TLR3 | abx415226 | Toll-Like Receptor 3 (TLR3) Antibody (FITC) | Mouse | Monoclonal | Rat | Toll-Like Receptor 3 (TLR3) | FITC | IF/ICC, FCM | 400 | 100 µg | Q99MB1 | RUO | |
Abbexa | TLR3 | abx415227 | Toll-Like Receptor 3 (TLR3) Antibody | Mouse | Monoclonal | Rat | Toll-Like Receptor 3 (TLR3) | Unconjugated | IF/ICC, FCM | 337.5 | 100 µg | Q99MB1 | RUO | |
Abbexa | TLR3 | abx102065 | Toll Like Receptor 3 (TLR3) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q99MB1 | RUO | |
Abbexa | TLR3 | abx130821 | Toll Like Receptor 3 (TLR3) Antibody | Rat | Polyclonal | Rabbit | Toll Like Receptor 3 (TLR3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR3 | abx069361 | Human Toll Like Receptor 3 (TLR3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 175 | 10 µg | O15455 | RUO |
Abbexa | TLR3 | abx069364 | Mouse Toll Like Receptor 3 (TLR3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q99MB1 | RUO |
Abbexa | TLR3 | abx168805 | Rat Toll Like Receptor 3 (TLR3) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | F1LN63 | RUO |
Abbexa | TLR3 | abx069362 | Mouse Toll Like Receptor 3 (TLR3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q99MB1 | RUO |
Abbexa | TLR3 | abx680463 | Human Toll Like Receptor 3 (TLR3) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 1 µg | RUO | |
Abbexa | TLR3 | abx069363 | Mouse Toll Like Receptor 3 (TLR3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q99MB1 | RUO |
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