Toll Like Receptor 3 (TLR3) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Toll Like Receptor 3 (TLR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx213506
tested applications
ELISA, WB
Description
TLR3 Antibody is a Rabbit Polyclonal against TLR3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Toll Like Receptor 3 (TLR3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15455 |
| Gene ID | 7098 |
| OMIM | 603029 |
| Alias | Toll-like receptor 3,CD283,IIAE2,IMD83, |
| Background | Antibody anti-TLR3 |
| Status | RUO |
Descripción
Toll-like receptor 3 (TLR3) is a crucial component of the innate immune system and plays a significant role in the detection of viral double-stranded RNA (dsRNA), a molecular pattern associated with viral infections. Unlike other TLRs, TLR3 is predominantly responsible for recognizing viral RNA rather than bacterial or fungal components, making it particularly important in antiviral immunity. TLR3 is expressed not only in immune cells like macrophages and dendritic cells but also in non-immune cells, such as epithelial cells and fibroblasts, which are often the first to encounter viral pathogens. Upon detecting dsRNA, TLR3 activates pathways leading to type I interferon production and pro-inflammatory cytokine release, which are essential for controlling viral infections and coordinating subsequent adaptive immune responses. TLR3 is primarily located in the endosomal membranes within cells, allowing it to recognize viral RNA that enters cells through phagocytosis or endocytosis. Its role in initiating antiviral responses makes it a subject of interest for immunological research and therapeutic interventions, particularly in viral diseases, immune disorders, and even cancer. TLR3 signaling pathways and its effects on cell function have also highlighted its involvement in other disease processes, where aberrant TLR3 activation may contribute to inflammation and tissue damage. Its unique function in antiviral immunity and role in a broader range of diseases positions TLR3 as a promising target for therapeutic modulation.
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