Mouse Toll Like Receptor 3 (TLR3) CLIA Kit

Product specifications

CLIA Kits

Toll Like Receptor 3 (TLR3)

Mouse

Chemiluminescent

Quantitative

Sandwich

5.49 pg/ml - 4000 pg/ml

< 1.93 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

CLIA

Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Shipped within 5-7 working days.

 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Toll-like receptor 3,CD283,IIAE2,IMD83,

CLIA Kits TLR3

RUO

The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Toll-like receptor 3 (TLR3) is a crucial component of the innate immune system and plays a significant role in the detection of viral double-stranded RNA (dsRNA), a molecular pattern associated with viral infections. Unlike other TLRs, TLR3 is predominantly responsible for recognizing viral RNA rather than bacterial or fungal components, making it particularly important in antiviral immunity. TLR3 is expressed not only in immune cells like macrophages and dendritic cells but also in non-immune cells, such as epithelial cells and fibroblasts, which are often the first to encounter viral pathogens. Upon detecting dsRNA, TLR3 activates pathways leading to type I interferon production and pro-inflammatory cytokine release, which are essential for controlling viral infections and coordinating subsequent adaptive immune responses. TLR3 is primarily located in the endosomal membranes within cells, allowing it to recognize viral RNA that enters cells through phagocytosis or endocytosis. Its role in initiating antiviral responses makes it a subject of interest for immunological research and therapeutic interventions, particularly in viral diseases, immune disorders, and even cancer. TLR3 signaling pathways and its effects on cell function have also highlighted its involvement in other disease processes, where aberrant TLR3 activation may contribute to inflammation and tissue damage. Its unique function in antiviral immunity and role in a broader range of diseases positions TLR3 as a promising target for therapeutic modulation.

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