Toll-Like Receptor 3 (TLR3) Antibody

Description

TLR3 Antibody is a Rabbit Polyclonal antibody against TLR3. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasmTLR3 functions as a receptor for double-stranded (ds)RNA typically associated with viral infectionIt was originally shown to be specifically expressed in dendritic cells of the leukocyte familyTLR3 has also been found in placenta and lung, and can be induced by LPS in a variety of tissuesTLR3 is predominantly localized to early endosomesBinding of dsRNA, or the analog polyinosine-polycytidylic acid (pIpC), to TLR3 triggers activation of transcription factors NF-κB and IRF3 through the adaptor protein TICAM-1/TRIFTRIF associates with members of the TRAF family and with RIP that combine to activate NF-κB and IRF3.