TLR3 antibody
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935106861
info@markelab.com
name
TLR3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08726
tested applications
ELISA, IHC
Description
Key component of innate and adaptive immunity. TLRs(Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | toll-like receptor 3 (TLR3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O15455 |
| Gene ID | 7098 |
| Alias | Toll-like receptor 3,CD283,IIAE2,IMD83, |
| Background | Antibody anti-TLR3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Toll-like receptor 3 (TLR3) is a crucial component of the innate immune system and plays a significant role in the detection of viral double-stranded RNA (dsRNA), a molecular pattern associated with viral infections. Unlike other TLRs, TLR3 is predominantly responsible for recognizing viral RNA rather than bacterial or fungal components, making it particularly important in antiviral immunity. TLR3 is expressed not only in immune cells like macrophages and dendritic cells but also in non-immune cells, such as epithelial cells and fibroblasts, which are often the first to encounter viral pathogens. Upon detecting dsRNA, TLR3 activates pathways leading to type I interferon production and pro-inflammatory cytokine release, which are essential for controlling viral infections and coordinating subsequent adaptive immune responses. TLR3 is primarily located in the endosomal membranes within cells, allowing it to recognize viral RNA that enters cells through phagocytosis or endocytosis. Its role in initiating antiviral responses makes it a subject of interest for immunological research and therapeutic interventions, particularly in viral diseases, immune disorders, and even cancer. TLR3 signaling pathways and its effects on cell function have also highlighted its involvement in other disease processes, where aberrant TLR3 activation may contribute to inflammation and tissue damage. Its unique function in antiviral immunity and role in a broader range of diseases positions TLR3 as a promising target for therapeutic modulation.
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TLR3 antibody
Key component of innate and adaptive immunity. TLRs(Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
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