Family main features
Toll-like receptor 2 (TLR2) is an essential component of the innate immune system, known for its role in recognizing and responding to pathogen-associated molecular patterns (PAMPs). TLR2 is part of the toll-like receptor (TLR) family, which detects structural components specific to pathogens and activates immune responses. TLR2 is particularly versatile, recognizing a broad array of ligands from bacteria, fungi, and viruses, and functions primarily by forming heterodimers with other TLRs, specifically TLR1 and TLR6. These heterodimers expand TLR2’s range of ligand recognition, including lipoproteins, lipopeptides, peptidoglycan, and lipoteichoic acid, enabling it to respond effectively to both Gram-positive and Gram-negative bacteria.
The expression of TLR2 is predominantly found in immune cells such as macrophages, dendritic cells, and monocytes. TLR2’s activity is integral to the initiation of pro-inflammatory responses that support early immune defense. As such, it plays a pivotal role in the development of both innate and adaptive immunity by bridging the two responses through cytokine release and antigen presentation. Due to its broad functionality and critical role in immunity, TLR2 has become a focus for research into infections, inflammation, and immune-related diseases, as well as a potential target for immunotherapy.
TLR2 consists of approximately 784 amino acids and is a type I transmembrane protein with distinct structural domains critical for its function:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain (TIR Domain):
TLR2 is classified as a member of the TLR family and is grouped with TLR1 and TLR6 in a subfamily based on structural similarities and dimerization capabilities. TLR2’s ability to form heterodimers with TLR1 and TLR6 allows it to detect a broader range of microbial components:
This versatility allows TLR2 to act as a broad-spectrum sensor within the immune system, recognizing a wide array of microbial components.
TLR2 has several key functions related to pathogen recognition and immune activation:
Ligand Recognition and Dimerization:
Signal Transduction:
Role in Host Defense and Inflammation:
Influence on Adaptive Immunity:
Aberrations in TLR2 function or expression have been associated with various infectious, autoimmune, and inflammatory diseases:
Infectious Diseases:
Autoimmune and Inflammatory Diseases:
Cancer:
Therapeutic Targeting:
TLR2 is a vital component of the innate immune system, enabling the detection of bacterial, fungal, and viral components. Through its extracellular leucine-rich repeat domains, TLR2 binds pathogen-associated molecules and, through dimerization with TLR1 or TLR6, broadens its ligand specificity. This dimerization and subsequent activation of downstream signaling pathways, including NF-κB and MAPK, initiate pro-inflammatory cytokine production and immune cell recruitment.
TLR2’s clinical relevance is evident in infectious diseases, autoimmune disorders, chronic inflammation, and cancer. Genetic variations in TLR2 can affect susceptibility to infections and inflammatory diseases, while chronic TLR2 activation can drive pathological inflammation. As a result, TLR2 is a target for therapeutic interventions aimed at modulating immune responses. By fine-tuning TLR2 activity, researchers aim to optimize immune responses in infections and inflammatory diseases and explore its potential in vaccine and cancer therapies.
toll like receptor 2 (TLR2)
Toll-like receptor 2,TIL4,CD282,Toll/interleukin-1 receptor-like protein 4
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con TLR2 - toll like receptor 2
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 67 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TLR2 | EB0069 | Bovine TLR2(Toll like receptor 2) ELISA Kit | bovine | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 1.563-100ng/ml | 96T | Q95LA9 | RUO | ||
Abbexa | TLR2 | abx257999 | Cow Toll Like Receptor 2 (TLR2) ELISA Kit | Cow | Saliva, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.118 ng/ml | 687.5 | 96 tests | Q95LA9 | RUO |
Abbexa | TLR2 | abx513649 | Dog Toll Like Receptor 2 (TLR2) ELISA Kit | Dog | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q689D1 | RUO | ||
FineTest | TLR2 | EH0300 | Human TLR2(Toll-like receptor 2) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | O60603 | RUO | ||
Abbexa | TLR2 | abx491846 | Human Toll Like Receptor 2 (TLR2) CLIA Kit | Human | Tissue homogenates, cell lysates, saliva, cell culture supernatants and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.115 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR2 | abx195371 | Human Toll Like Receptor 2 (TLR2) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR2 | abx572097 | Low Sample Volume Human Toll Like Receptor 2 (TLR2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 600 | 96 tests | O60603 | RUO |
Abbexa | TLR2 | abx153342 | Human Toll Like Receptor 2 (TLR2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 525 | 96 tests | RUO | |
FineTest | TLR2 | EMK0077 | Monkey TLR2(Toll-Like Receptor 2) ELISA Kit | monkey | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | Q95M53 | RUO | ||
Abbexa | TLR2 | abx255409 | Monkey Toll Like Receptor 2 (TLR2) ELISA Kit | Monkey | Serum, plasma and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 687.5 | 96 tests | RUO | |
FineTest | TLR2 | EM0182 | Mouse TLR2(Toll-like receptor 2) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | Q9QUN7 | RUO | ||
Abbexa | TLR2 | abx254557 | Mouse Toll Like Receptor 2 (TLR2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 562.5 | 96 tests | Q9QUN7 | RUO |
Abbexa | TLR2 | abx491847 | Mouse Toll Like Receptor 2 (TLR2) CLIA Kit | Mouse | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.112 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR2 | abx154784 | Mouse Toll Like Receptor 2 (TLR2) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.14 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR2 | abx255571 | Pig Toll Like Receptor 2 (TLR2) ELISA Kit | Pig | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 0.47 ng/ml | 712.5 | 96 tests | RUO | |
FineTest | TLR2 | ER1387 | Rat TLR2(Toll-Like Receptor 2) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | E9PTD9 | RUO | ||
Abbexa | TLR2 | abx256053 | Rat Toll Like Receptor 2 (TLR2) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 525 | 96 tests | E9PTD9 | RUO |
Abbexa | TLR2 | abx156174 | Rat Toll Like Receptor 2 (TLR2) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 675 | 96 tests | RUO | |
Abbexa | TLR2 | abx195372 | Rat Toll Like Receptor 2 (TLR2) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR2 | abx491848 | Rat Toll Like Receptor 2 (TLR2) CLIA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.122 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TLR2 | FNab09836 | anti- TLR2 antibody | human | monoclonal | Mouse | toll-like receptor 2 | IgG2a | Unconjugated | ELISA, WB | 100µg | O60603 | RUO | |
FineTest | TLR2 | FNab10498 | anti-TLR2 antibody | human | polyclonal | Rabbit | Toll-like receptor 2 | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | O60603 | RUO | |
Abbexa | TLR2 | abx224396 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, IF/ICC | 362.5 | 100 µl | O60603 | RUO | |
Abbexa | TLR2 | abx027542 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB | 250 | 80 µl | O60603 | RUO | |
Abbexa | TLR2 | abx028479 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | O60603 | RUO | |
Abbexa | TLR2 | abx102058 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | O60603 | RUO | |
Abbexa | TLR2 | abx108812 | Toll Like Receptor 2 (TLR2) Antibody (HRP) | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | HRP | ELISA | 162.5 | 20 µg | O60603 | RUO | |
Abbexa | TLR2 | abx270405 | Toll Like Receptor 2 (TLR2) Antibody (FITC) | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | FITC | FCM | 475 | 100 tests | RUO | ||
Abbexa | TLR2 | abx270637 | Toll Like Receptor 2 (TLR2) Antibody (APC) | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | APC | FCM | 662.5 | 100 tests | RUO | ||
Abbexa | TLR2 | abx270869 | Toll Like Receptor 2 (TLR2) Antibody (PE) | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | PE | FCM | 575 | 100 tests | RUO | ||
Abbexa | TLR2 | abx105977 | Toll Like Receptor 2 (TLR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Biotin | ELISA | 162.5 | 20 µg | O60603 | RUO | |
Abbexa | TLR2 | abx370287 | Toll Like Receptor 2 (TLR2) Antibody Pair | Human | Toll Like Receptor 2 (TLR2) | ELISA | 975 | 5 × 96 tests | RUO | |||||
Abbexa | TLR2 | abx412013 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC | 462.5 | 100 µg | O60603 | RUO | |
Abbexa | TLR2 | abx414263 | Toll Like Receptor 2 (TLR2) Antibody (PE) | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | PE | FCM | 487.5 | 100 tests | O60603 | RUO | |
Abbexa | TLR2 | abx011833 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB | 362.5 | 100 µl | O60603 | RUO | |
Abbexa | TLR2 | abx107392 | Toll Like Receptor 2 (TLR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | FITC | 162.5 | 20 µg | O60603 | RUO | ||
Abbexa | TLR2 | abx224269 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | ELISA, WB | 362.5 | 100 µl | O60603 | RUO | ||
Abbexa | TLR2 | abx239892 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB | 350 | 100 µg | O60603 | RUO | |
Abbexa | TLR2 | abx102059 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | O60603 | RUO | |
Abbexa | TLR2 | abx102060 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | TLR2 | abx274516 | Toll Like Receptor 2 (TLR2) Antibody (Biotin) | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Biotin | ELISA, WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TLR2 | abx102061 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O60603 | RUO | |
Abbexa | TLR2 | abx273768 | Toll Like Receptor 2 (TLR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | FITC | WB, IHC, IF/ICC | 400 | 200 µl | RUO | ||
Abbexa | TLR2 | abx270107 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | TLR2 | abx272025 | Toll Like Receptor 2 (TLR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Biotin | WB, IHC, IF/ICC | 337.5 | 200 µl | RUO | ||
Abbexa | TLR2 | abx137432 | Toll Like Receptor 2 (TLR2) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | TLR2 | abx110267 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA | 162.5 | 20 µg | O60603 | RUO | |
Abbexa | TLR2 | abx414262 | Toll Like Receptor 2 (TLR2) Antibody (FITC) | Human | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | FITC | FCM | 400 | 100 µg | O60603 | RUO | |
Abbexa | TLR2 | abx212687 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | O60603 | RUO | |
Abbexa | TLR2 | abx212303 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O60603 | RUO | |
Abbexa | TLR2 | abx212686 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | O60603 | RUO | |
Abbexa | TLR2 | abx212302 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O60603 | RUO | |
Abbexa | TLR2 | abx326823 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | O60603 | RUO | |
Abbexa | TLR2 | abx001983 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IF/ICC | 175 | 20 µl | O60603 | RUO | |
Abbexa | TLR2 | abx147259 | Toll Like Receptor 2 (TLR2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | O60603 | RUO | |
Abbexa | TLR2 | abx028480 | Toll Like Receptor 2 (TLR2) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q9QUN7 | RUO | |
Abbexa | TLR2 | abx129332 | Toll Like Receptor 2 (TLR2) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QUN7 | RUO | |
Abbexa | TLR2 | abx370561 | Toll Like Receptor 2 (TLR2) Antibody Pair | Mouse | Toll Like Receptor 2 (TLR2) | ELISA | 1350 | 5 × 96 tests | RUO | |||||
Abbexa | TLR2 | abx102062 | Toll Like Receptor 2 (TLR2) Antibody | Rat | Polyclonal | Rabbit | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | E9PTD9 | RUO | |
Abbexa | TLR2 | abx174839 | Toll Like Receptor 2 (TLR2) Antibody | Rat | Monoclonal | Mouse | Toll Like Receptor 2 (TLR2) | Unconjugated | WB, IHC, IF/ICC | 775 | 1 ml | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR2 | abx069359 | Rat Toll Like Receptor 2 (TLR2) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | E9PTD9 | RUO |
Abbexa | TLR2 | abx069360 | Human Toll Like Receptor 2 (TLR2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | O60603 | RUO |
Abbexa | TLR2 | abx167213 | Mouse Toll Like Receptor 2 (TLR2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9QUN7 | RUO |
Abbexa | TLR2 | abx680216 | Human Toll Like Receptor 2 (TLR2) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 1 µg | RUO | |
Abbexa | TLR2 | abx069358 | Human Toll Like Receptor 2 (TLR2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | O60603 | RUO |
Abbexa | TLR2 | abx692566 | Mouse Toll Like Receptor 2 (TLR2) Protein | Mouse | Recombinant | Insect | SDS-PAGE | 837.5 | 100 µg | Q9QUN7 | RUO | |
Abbexa | TLR2 | abx680018 | Mouse Toll Like Receptor 2 (TLR2) Protein | Mouse | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 1 µg | RUO |
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