Human Toll Like Receptor 2 (TLR2) Protein
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935106861
info@markelab.com
Precio
195€ (10 µg)
Protein TLR2
proveedor
Abbexareference
abx069360Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Toll Like Receptor 2 (TLR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Toll-like receptor 2 (TLR2) is an essential component of the innate immune system, known for its role in recognizing and responding to pathogen-associated molecular patterns (PAMPs). TLR2 is part of the toll-like receptor (TLR) family, which detects structural components specific to pathogens and activates immune responses. TLR2 is particularly versatile, recognizing a broad array of ligands from bacteria, fungi, and viruses, and functions primarily by forming heterodimers with other TLRs, specifically TLR1 and TLR6. These heterodimers expand TLR2’s range of ligand recognition, including lipoproteins, lipopeptides, peptidoglycan, and lipoteichoic acid, enabling it to respond effectively to both Gram-positive and Gram-negative bacteria. The expression of TLR2 is predominantly found in immune cells such as macrophages, dendritic cells, and monocytes. TLR2’s activity is integral to the initiation of pro-inflammatory responses that support early immune defense. As such, it plays a pivotal role in the development of both innate and adaptive immunity by bridging the two responses through cytokine release and antigen presentation. Due to its broad functionality and critical role in immunity, TLR2 has become a focus for research into infections, inflammation, and immune-related diseases, as well as a potential target for immunotherapy.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Toll Like Receptor 2 (TLR2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 22.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe644-Ser784 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TLR2
dry ice
No
availability
Shipped within 5-12 working days.
alias
Toll-like receptor 2,TIL4,CD282,Toll/interleukin-1 receptor-like protein 4
uniprot id
NCBI accession
NP_003255.2
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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