Human Toll Like Receptor 2 (TLR2) Protein

Este producto es parte de TLR2 - toll like receptor 2
Human Toll Like Receptor 2 (TLR2) Protein

Pida mas información

935106861

info@markelab.com

Precio

195€ (10 µg)

Protein TLR2

proveedor

Abbexa

reference

abx069360

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Toll Like Receptor 2 (TLR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Toll-like receptor 2 (TLR2) is an essential component of the innate immune system, known for its role in recognizing and responding to pathogen-associated molecular patterns (PAMPs). TLR2 is part of the toll-like receptor (TLR) family, which detects structural components specific to pathogens and activates immune responses. TLR2 is particularly versatile, recognizing a broad array of ligands from bacteria, fungi, and viruses, and functions primarily by forming heterodimers with other TLRs, specifically TLR1 and TLR6. These heterodimers expand TLR2’s range of ligand recognition, including lipoproteins, lipopeptides, peptidoglycan, and lipoteichoic acid, enabling it to respond effectively to both Gram-positive and Gram-negative bacteria. The expression of TLR2 is predominantly found in immune cells such as macrophages, dendritic cells, and monocytes. TLR2’s activity is integral to the initiation of pro-inflammatory responses that support early immune defense. As such, it plays a pivotal role in the development of both innate and adaptive immunity by bridging the two responses through cytokine release and antigen presentation. Due to its broad functionality and critical role in immunity, TLR2 has become a focus for research into infections, inflammation, and immune-related diseases, as well as a potential target for immunotherapy.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Toll Like Receptor 2 (TLR2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 22.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe644-Ser784 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TLR2


dry ice

No


availability

Shipped within 5-12 working days.


alias

Toll-like receptor 2,TIL4,CD282,Toll/interleukin-1 receptor-like protein 4


NCBI accession

NP_003255.2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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