Family main features
SLAMF8 (Signaling Lymphocytic Activation Molecule Family Member 8) is a cell-surface receptor protein that is part of the SLAM (Signaling Lymphocyte Activation Molecule) family, a subgroup of the immunoglobulin (Ig) superfamily. SLAM family receptors, including SLAMF8, are involved in immune cell communication, with significant roles in immune regulation and inflammation. SLAMF8 is expressed primarily on macrophages, dendritic cells, neutrophils, and monocytes and is notable for its involvement in immune cell activation, particularly in response to infections and inflammatory stimuli.
Unlike other SLAM family members, SLAMF8 does not interact with the adaptor molecule SAP (SLAM-associated protein) for signaling. Instead, it appears to have a distinctive signaling pathway, involving interactions with other signaling molecules to modulate immune responses. SLAMF8 has been implicated in the regulation of reactive oxygen species (ROS) production, phagocytosis, and inflammatory cytokine production, which contribute to the host defense against pathogens. It plays an important role in modulating innate immune responses, helping balance pro- and anti-inflammatory signals during infection and inflammation.
SLAMF8 is a type I transmembrane protein composed of approximately 220 amino acids. The structural features of SLAMF8 include:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic (Intracellular) Domain:
SLAMF8 belongs to the SLAM family within the larger immunoglobulin superfamily, which includes several related receptors such as SLAMF1 (CD150), SLAMF2 (CD48), SLAMF3, SLAMF4, and SLAMF7. These receptors are primarily associated with modulating immune responses, particularly in lymphocytes and other immune cells. SLAMF8 does not have known subtypes or isoforms, but it shares structural and functional similarities with other SLAM family members, though with a unique non-SAP-dependent signaling mechanism.
Modulation of Immune Cell Activation:
Role in Phagocytosis and Inflammation:
Regulation of Innate Immune Responses:
Influence on Disease Susceptibility:
Autoimmune and Inflammatory Disorders:
Infectious Diseases:
Cancer:
SLAMF8 is a member of the SLAM family, which is involved in immune cell regulation and communication. Uniquely among SLAM receptors, SLAMF8 does not rely on the SAP signaling pathway and instead utilizes alternative intracellular signaling adaptors to exert its effects, particularly in macrophages, neutrophils, and dendritic cells. SLAMF8's extracellular Ig-like domain enables it to mediate immune cell interactions, while its intracellular domain allows for non-SAP-dependent signaling, distinguishing it from other SLAM family members.
Functionally, SLAMF8 modulates reactive oxygen species production, phagocytosis, and cytokine production in response to microbial and inflammatory stimuli. This receptor plays a critical role in regulating innate immune responses, particularly those involving macrophages and neutrophils. By controlling ROS production and cytokine release, SLAMF8 helps balance the immune response, preventing both under-activation and over-activation that could lead to infection susceptibility or excessive inflammation, respectively.
Clinically, SLAMF8 has implications in autoimmune diseases, infectious diseases, and potentially in cancer, where its function in immune regulation may influence disease progression or immune response efficacy. Due to its central role in modulating inflammatory and immune processes, SLAMF8 continues to be a focus of research as a potential therapeutic target for modulating immune responses in various disease contexts.
SLAM family member 8 (SLAMF8 )
B-lymphocyte activator macrophage expressed,BLAME,CD353,SBBI42,BCM-like membrane protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con SLAMF8 - SLAM family member 8
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Esta página contiene 14 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SLAMF8 | abx546081 | Human SLAM family member 8 (SLAMF8) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9P0V8 | RUO | ||
Abbexa | SLAMF8 | abx546082 | Mouse SLAM family member 8 (SLAMF8) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9D3G2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SLAMF8 | abx305324 | SLAMF8 Antibody (Biotin) | Human | Polyclonal | Rabbit | SLAMF8 | Biotin | ELISA | 162.5 | 20 µg | Q9P0V8 | RUO | |
Abbexa | SLAMF8 | abx305322 | SLAMF8 Antibody (HRP) | Human | Polyclonal | Rabbit | SLAMF8 | HRP | ELISA | 162.5 | 20 µg | Q9P0V8 | RUO | |
Abbexa | SLAMF8 | abx433278 | SLAM Family Member 8 (SLAMF8) Antibody | Human | Polyclonal | Goat | SLAM Family Member 8 (SLAMF8) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | SLAMF8 | abx339864 | SLAM Family Member 8 (SLAMF8) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 8 (SLAMF8) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9P0V8 | RUO | |
Abbexa | SLAMF8 | abx305323 | SLAMF8 Antibody (FITC) | Human | Polyclonal | Rabbit | SLAMF8 | FITC | 162.5 | 20 µg | Q9P0V8 | RUO | ||
Abbexa | SLAMF8 | abx027070 | SLAM Family Member 8 (SLAMF8) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 8 (SLAMF8) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q9P0V8 | RUO | |
Abbexa | SLAMF8 | abx432189 | SLAM Family Member 8 (SLAMF8) Antibody | Human | Polyclonal | Goat | SLAM Family Member 8 (SLAMF8) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | SLAMF8 | abx339865 | SLAM Family Member 8 (SLAMF8) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 8 (SLAMF8) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9P0V8 | RUO | |
Abbexa | SLAMF8 | abx301283 | SLAM Family Member 8 (SLAMF8) Antibody | Human | Polyclonal | Rabbit | SLAM Family Member 8 (SLAMF8) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q9P0V8 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | SLAMF8 | abx690830 | Mouse SLAM Family Member 8 (SLAMF8) Protein | Mouse | Recombinant | Human | SDS-PAGE | 212.5 | 10 µg | Q9D3G2 | RUO | |
Abbexa | SLAMF8 | abx690725 | Human SLAM Family Member 8 (SLAMF8) Protein | Human | Recombinant | Human | SDS-PAGE | 225 | 10 µg | Q9P0V8 | RUO | |
Abbexa | SLAMF8 | abx692098 | Mouse SLAM Family Member 8 (SLAMF8) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO |
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