Mouse SLAM Family Member 8 (SLAMF8) Protein (Active)
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse SLAM Family Member 8 (SLAMF8) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692098
tested applications
SDS-PAGE
Description
Mouse SLAMF8 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse SLAMF8 (NP_083360.2) extracellular domain (Met 1-Asp 231) was fused with the a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | SLAMF8 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 24.8 kDa Sequence Fragment: Met1-Asp231 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 80% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_083360.2 |
| Alias | B-lymphocyte activator macrophage expressed,BLAME,CD353,SBBI42,BCM-like membrane protein |
| Background | Protein SLAMF8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SLAMF8 (Signaling Lymphocytic Activation Molecule Family Member 8) is a cell-surface receptor protein that is part of the SLAM (Signaling Lymphocyte Activation Molecule) family, a subgroup of the immunoglobulin (Ig) superfamily. SLAM family receptors, including SLAMF8, are involved in immune cell communication, with significant roles in immune regulation and inflammation. SLAMF8 is expressed primarily on macrophages, dendritic cells, neutrophils, and monocytes and is notable for its involvement in immune cell activation, particularly in response to infections and inflammatory stimuli. Unlike other SLAM family members, SLAMF8 does not interact with the adaptor molecule SAP (SLAM-associated protein) for signaling. Instead, it appears to have a distinctive signaling pathway, involving interactions with other signaling molecules to modulate immune responses. SLAMF8 has been implicated in the regulation of reactive oxygen species (ROS) production, phagocytosis, and inflammatory cytokine production, which contribute to the host defense against pathogens. It plays an important role in modulating innate immune responses, helping balance pro- and anti-inflammatory signals during infection and inflammation.
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