SLAM Family Member 8 (SLAMF8) Antibody
260€ (50 µl)
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935106861
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name
SLAM Family Member 8 (SLAMF8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx339864
tested applications
ELISA, IHC
Description
SLAMF8 Antibody is a Rabbit Polyclonal against SLAMF8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SLAM Family Member 8 (SLAMF8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9P0V8 |
| Gene ID | 56833 |
| Alias | B-lymphocyte activator macrophage expressed,BLAME,CD353,SBBI42,BCM-like membrane protein |
| Background | Antibody anti-SLAMF8 |
| Status | RUO |
Descripción
SLAMF8 (Signaling Lymphocytic Activation Molecule Family Member 8) is a cell-surface receptor protein that is part of the SLAM (Signaling Lymphocyte Activation Molecule) family, a subgroup of the immunoglobulin (Ig) superfamily. SLAM family receptors, including SLAMF8, are involved in immune cell communication, with significant roles in immune regulation and inflammation. SLAMF8 is expressed primarily on macrophages, dendritic cells, neutrophils, and monocytes and is notable for its involvement in immune cell activation, particularly in response to infections and inflammatory stimuli. Unlike other SLAM family members, SLAMF8 does not interact with the adaptor molecule SAP (SLAM-associated protein) for signaling. Instead, it appears to have a distinctive signaling pathway, involving interactions with other signaling molecules to modulate immune responses. SLAMF8 has been implicated in the regulation of reactive oxygen species (ROS) production, phagocytosis, and inflammatory cytokine production, which contribute to the host defense against pathogens. It plays an important role in modulating innate immune responses, helping balance pro- and anti-inflammatory signals during infection and inflammation.
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