Human SLAM Family Member 8 (SLAMF8) Protein

Product specifications

Proteins and Peptides

Slam Family Member 8 (SLAMF8)

HEK293 cells

Activity: Not tested
Sequence Fragment: Ala23-Asp233
Tag: C-terminal 6 His tag

Human

Calculated MW: 26.2 kDa  Observed MW (SDS-PAGE): 34 kDa

Recombinant

> 95% (SDS-PAGE)

0.2 µm filtered prior to lyophilization.

10 µg

50 µg

Lyophilized

SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80.

Shipped within 5-15 working days.

Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.

No

Q9P0V8

56833

606620

B-lymphocyte activator macrophage expressed,BLAME,CD353,SBBI42,BCM-like membrane protein

Protein SLAMF8

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

SLAMF8 (Signaling Lymphocytic Activation Molecule Family Member 8) is a cell-surface receptor protein that is part of the SLAM (Signaling Lymphocyte Activation Molecule) family, a subgroup of the immunoglobulin (Ig) superfamily. SLAM family receptors, including SLAMF8, are involved in immune cell communication, with significant roles in immune regulation and inflammation. SLAMF8 is expressed primarily on macrophages, dendritic cells, neutrophils, and monocytes and is notable for its involvement in immune cell activation, particularly in response to infections and inflammatory stimuli. Unlike other SLAM family members, SLAMF8 does not interact with the adaptor molecule SAP (SLAM-associated protein) for signaling. Instead, it appears to have a distinctive signaling pathway, involving interactions with other signaling molecules to modulate immune responses. SLAMF8 has been implicated in the regulation of reactive oxygen species (ROS) production, phagocytosis, and inflammatory cytokine production, which contribute to the host defense against pathogens. It plays an important role in modulating innate immune responses, helping balance pro- and anti-inflammatory signals during infection and inflammation.

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This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.

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