Family main features
Peptidase Inhibitor 16 (PI16), also known as PSPBP (prostate secretory protein binding protein), is a member of the peptidase inhibitor family that plays a role in regulating protease activity in various tissues, particularly in the cardiovascular, immune, and reproductive systems. PI16 is a secreted protein expressed primarily by stromal fibroblasts, prostate cells, and cardiac tissues, among others. It has been identified as an immunomodulatory molecule and a marker for fibroblasts, especially those involved in tissue remodeling processes. By modulating protease activity, PI16 indirectly influences extracellular matrix (ECM) composition and cellular signaling, contributing to processes like fibrosis, inflammation, and cardiac function. Given its tissue-specific expression and involvement in immune responses, PI16 has been the subject of studies focused on its roles in cardiovascular diseases, cancer, and immune regulation.
PI16 is a single-chain polypeptide with approximately 463 amino acids, containing a cysteine-rich N-terminal domain and a C-terminal region that includes the characteristic peptidase inhibitor domain:
N-terminal Domain:
Peptidase Inhibitor Domain (C-terminal Domain):
PI16 belongs to the larger family of peptidase inhibitors, specifically within the Kazal-type serine protease inhibitor family. Kazal-type inhibitors are known for their capacity to tightly bind and inhibit serine proteases, contributing to various biological functions by regulating protease activity in tissues. PI16 has unique characteristics and distinct expression patterns compared to other members of this family, making it a unique regulator of protease activity, particularly in fibroblast and immune cell populations.
Currently, there are no known subtypes or isoforms of PI16, although it may undergo post-translational modifications that influence its binding affinity and inhibitory efficacy. Research is ongoing to determine if alternative splicing or mutations in PI16 can result in functional variations, particularly in disease contexts where PI16 levels are altered.
The primary function of PI16 is to inhibit protease activity in various tissues, modulating the extracellular environment and immune responses:
Protease Inhibition:
Role in Fibrosis and ECM Remodeling:
Immune Modulation:
Potential Role in Cancer:
Cardiovascular Health:
Cardiovascular Disease:
Cancer:
Fibrotic Diseases:
Autoimmune and Inflammatory Disorders:
Peptidase Inhibitor 16 (PI16) is a protease inhibitor with a key role in regulating ECM composition and protease activity in various tissues. Structurally, PI16 comprises a cysteine-rich N-terminal domain for stability and a C-terminal Kazal-type domain that enables it to bind and inhibit specific serine proteases. This structure allows PI16 to modulate protease activity in processes such as ECM remodeling, tissue fibrosis, immune modulation, and cardiovascular health.
Functionally, PI16 is crucial for maintaining tissue integrity during inflammatory responses and plays a regulatory role in tissue remodeling, particularly in fibrotic and cancerous tissues. Its expression in fibroblasts and immune cells highlights its importance in the ECM and immune interactions, where it modulates responses to injury, inflammation, and tumorigenesis. PI16’s role in fibrosis, cancer, cardiovascular health, and immune modulation also underscores its potential as a therapeutic target and biomarker in various clinical contexts.
In clinical settings, PI16 holds potential as a biomarker for diseases involving ECM remodeling, such as cardiac fibrosis, cancer, and fibrotic diseases. In cancer, PI16 is involved in ECM remodeling in the tumor microenvironment, supporting tumor growth and invasion. Given its regulatory roles across these conditions, PI16 presents a promising target for therapeutic intervention in diseases characterized by abnormal ECM dynamics, fibrosis, and immune dysregulation.
peptidase inhibitor 16 (PI16)
CD364,PSPBP,CRISP9,MSMBBP,PI-16,Cysteine-rich secretory protein 9,PSP94-binding protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con PI16 - peptidase inhibitor 16
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 21 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PI16 | abx152731 | Human Peptidase Inhibitor 16 (PI16) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.65 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | PI16 | abx496213 | Human Peptidase Inhibitor 16 (PI16) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.064 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | PI16 | abx353186 | Mouse Peptidase Inhibitor 16 (PI16) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.62 ng/ml | 743.75 | 96 tests | Q9ET66 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PI16 | abx104788 | Peptidase Inhibitor 16 (PI16) Antibody | Cow | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | WB, IHC, IF/ICC | 325 | 100 µl | RUO | ||
FineTest | PI16 | FNab06415 | anti- PI16 antibody | human | polyclonal | Rabbit | peptidase inhibitor 16 | IgG | Unconjugated | ELISA, WB | 100µg | Q6UXB8 | RUO | |
Abbexa | PI16 | abx270389 | Peptidase Inhibitor 16 (PI16) Antibody (FITC) | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | FITC | FCM | 662.5 | 200 tests | RUO | ||
Abbexa | PI16 | abx270091 | Peptidase Inhibitor 16 (PI16) Antibody | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | FCM | 312.5 | 50 tests | RUO | ||
Abbexa | PI16 | abx029735 | Peptidase Inhibitor 16 (PI16) Antibody | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | ELISA, WB | 250 | 80 µl | Q6UXB8 | RUO | |
Abbexa | PI16 | abx173977 | Peptidase Inhibitor 16 (PI16) Antibody | Human | Monoclonal | Mouse | Peptidase Inhibitor 16 (PI16) | Unconjugated | WB, IHC, IF/ICC | 300 | 100 µl | Q6UXB8 | RUO | |
Abbexa | PI16 | abx236415 | Peptidase Inhibitor 16 (PI16) Antibody | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | ELISA, WB | 350 | 100 µg | Q6UXB8 | RUO | |
Abbexa | PI16 | abx270853 | Peptidase Inhibitor 16 (PI16) Antibody (PE) | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | PE | FCM | 800 | 200 tests | RUO | ||
Abbexa | PI16 | abx271879 | Peptidase Inhibitor 16 (PI16) Antibody (Biotin) | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Biotin | WB, IHC, IF/ICC | 387.5 | 200 µl | RUO | ||
Abbexa | PI16 | abx270621 | Peptidase Inhibitor 16 (PI16) Antibody (APC) | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | APC | FCM | 937.5 | 200 tests | RUO | ||
Abbexa | PI16 | abx102279 | Peptidase Inhibitor 16 (PI16) Antibody | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q6UXB8 | RUO | |
Abbexa | PI16 | abx375972 | Peptidase Inhibitor 16 (PI16) Antibody | Human | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q6UXB8 | RUO | |
Abbexa | PI16 | abx272981 | Peptidase Inhibitor 16 (PI16) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Biotin | WB, IHC, IF/ICC | 400 | 200 µl | RUO | ||
Abbexa | PI16 | abx102280 | Peptidase Inhibitor 16 (PI16) Antibody | Mouse | Polyclonal | Rabbit | Peptidase Inhibitor 16 (PI16) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PI16 | abx068448 | Human Peptidase Inhibitor 16 (PI16) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q6UXB8 | RUO |
Abbexa | PI16 | abx073706 | Human Peptidase Inhibitor 16 (PI16) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 225 | 2 µg | Q6UXB8 | RUO | |
Abbexa | PI16 | abx168005 | Cow Peptidase Inhibitor 16 (PI16) Protein | Cow | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 412.5 | 50 µg | Q58D34 | RUO |
Abbexa | PI16 | abx068449 | Mouse Peptidase Inhibitor 16 (PI16) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO |
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