Family main features
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is a soluble member of the immunoglobulin superfamily and is structurally similar to LAIR1. Unlike LAIR1, which is a membrane-bound receptor, LAIR2 is found freely in extracellular fluids and serves as a natural decoy receptor. LAIR2 primarily binds to collagen and collagen-like molecules in the extracellular matrix (ECM) and modulates immune responses by blocking the collagen-binding sites of LAIR1. By competing with LAIR1 for ligand binding, LAIR2 plays a significant role in fine-tuning immune responses, particularly in collagen-rich tissues.
LAIR2 is predominantly expressed in various immune tissues, such as the spleen, bone marrow, and lymph nodes, and circulates in the blood. It interacts with collagen and similar ECM proteins, influencing immune regulation in areas where collagen is abundant. LAIR2’s decoy function allows it to block the inhibitory effects of LAIR1, effectively providing a modulatory balance to the immune system and ensuring appropriate immune responses. This role is particularly important in the contexts of inflammation, infection, cancer, and autoimmune diseases.
The structure of LAIR2 is simpler compared to LAIR1, reflecting its function as a soluble decoy receptor rather than a signaling receptor on cell surfaces. Key structural features include:
Immunoglobulin (Ig)-like Extracellular Domain:
Absence of Transmembrane and Intracellular Domains:
The overall structure of LAIR2 is highly specialized for binding collagen and other related ligands, but it does not participate in signaling directly. Its structural simplicity compared to LAIR1 reflects its specialized role as a decoy receptor.
LAIR2 is part of the leukocyte-associated immunoglobulin-like receptor (LAIR) family, which includes both LAIR1 and LAIR2. This family is within the broader immunoglobulin superfamily (IgSF), which includes a range of immune-related receptors. LAIR2 does not have further subtypes but shares significant structural homology with LAIR1, particularly in its Ig-like domain. This similarity is essential for its decoy function, allowing it to compete effectively with LAIR1 for collagen binding.
Decoy Function in Immune Regulation:
Immune Modulation and Inflammation:
Potential Role in Cancer:
Role in Autoimmune Diseases:
Cancer Immunotherapy:
Autoimmune and Inflammatory Diseases:
Infectious Diseases:
LAIR2, or leukocyte-associated immunoglobulin-like receptor 2, is a soluble immunoglobulin-like receptor that functions as a decoy receptor in the immune system. It binds to collagen in the extracellular matrix, preventing LAIR1 from engaging with its ligands and thereby blocking the inhibitory signaling that would otherwise suppress immune responses. This function is essential for regulating immune responses, especially in collagen-rich environments where immune cell inhibition may be contextually inappropriate, such as during infections or tumor responses.
Structurally, LAIR2 is defined by a single Ig-like domain that closely resembles that of LAIR1, enabling it to bind collagen and other similar ligands effectively. Unlike LAIR1, LAIR2 lacks transmembrane and intracellular domains, making it a soluble protein that circulates in the extracellular space without engaging in intracellular signaling.
LAIR2’s decoy function is biologically significant in various contexts, including inflammation, infection, cancer, and autoimmunity. By counteracting the effects of LAIR1, LAIR2 helps to maintain a balance between immune activation and inhibition, ensuring that immune cells can respond appropriately to various challenges. This function has implications for diseases where immune regulation is disrupted, such as cancer, where tumors exploit collagen to suppress immune responses, and autoimmune diseases, where dysregulated immune responses target host tissues.
Clinically, LAIR2 is being explored as a potential therapeutic target in cancer immunotherapy, autoimmune disease management, and infectious diseases. By blocking LAIR1-mediated inhibition, LAIR2 may enhance immune activation where needed, offering therapeutic benefits in conditions that require modulated immune responses. LAIR2’s role as a natural immune modulator underscores its importance in maintaining immune homeostasis and highlights its potential for therapeutic applications across various disease contexts.
leukocyte associated immunoglobulin like receptor 2 (LAIR2)
Leukocyte-associated immunoglobulin-like receptor 2,CD306,LAIR-2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con LAIR2 - leukocyte associated immunoglobulin like receptor 2
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | LAIR2 | abx152154 | Human Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.4 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | LAIR2 | abx492310 | Human Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) CLIA Kit | Human | Serum, plasma, urine, tissue homogenates and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.4 pg/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LAIR2 | abx339319 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q6ISS4 | RUO | |
Abbexa | LAIR2 | abx304326 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | Biotin | ELISA | 162.5 | 20 µg | Q6ISS4 | RUO | |
Abbexa | LAIR2 | abx173345 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody | Human | Monoclonal | Mouse | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | LAIR2 | abx304324 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (HRP) | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | HRP | ELISA | 162.5 | 20 µg | Q6ISS4 | RUO | |
Abbexa | LAIR2 | abx104584 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | Q6ISS4 | RUO | |
Abbexa | LAIR2 | abx304323 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q6ISS4 | RUO | |
Abbexa | LAIR2 | abx304325 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | FITC | 162.5 | 20 µg | Q6ISS4 | RUO | ||
Abbexa | LAIR2 | abx211841 | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q6ISS4 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LAIR2 | abx067774 | Human Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q6ISS4 | RUO |
Abbexa | LAIR2 | abx694106 | Human Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | Q6ISS4 | RUO | |
Abbexa | LAIR2 | abx261907 | Leukocyte-Associated Ig-Like Receptor 2 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q6ISS4 | RUO |
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