Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (HRP)
169€ (20 µg)
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935106861
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name
Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx304324
tested applications
ELISA
Description
LAIR2 Antibody (HRP) is a Rabbit Polyclonal against LAIR2 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ISS4 |
| Gene ID | 3904 |
| NCBI Accession | NP_002279.2, NM_002288.5, NP_067154.1, NM_021270.4 |
| OMIM | 602993 |
| Alias | Leukocyte-associated immunoglobulin-like receptor 2,CD306,LAIR-2 |
| Background | Antibody anti-LAIR2 |
| Status | RUO |
Descripción
Leukocyte Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a soluble immunoregulatory protein belonging to the immunoglobulin superfamily. LAIR2 functions primarily as a natural inhibitor of immune activation by competing with its membrane-bound counterpart, LAIR1, for binding to collagens present in the extracellular matrix. This competitive binding prevents LAIR1-mediated inhibitory signaling on immune cells such as T cells, natural killer (NK) cells, and dendritic cells, which are crucial for maintaining immune homeostasis and preventing excessive immune activation. LAIR2 is expressed predominantly in immune-related tissues, including the spleen, bone marrow, and lymph nodes, and its soluble nature allows it to circulate freely in the bloodstream, acting as a systemic modulator of collagen-induced immunosuppression. Dysregulated LAIR2 expression has been implicated in various pathological conditions, such as autoimmune diseases, where its elevated levels may counteract excessive immune inhibition, or in cancers, where it could interfere with tumor-induced immunosuppressive microenvironments. Therapeutically, LAIR2 has shown promise as a biomarker for immune dysregulation and as a potential agent in immunotherapy strategies aimed at mitigating immune suppression in cancers or promoting immune tolerance in autoimmune disorders. Its precise role and interactions with other immune checkpoints continue to be a subject of active research, with a focus on leveraging its properties for clinical applications in immune modulation.
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