Human Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Protein

Este producto es parte de LAIR2 - leukocyte associated immunoglobulin like receptor 2
Product Graph
195€ (10 µg)

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935106861
info@markelab.com
name
Human Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067774
tested applications
WB, SDS-PAGE

Description

Recombinant Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 15.7 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Thr21-Pro152

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q6ISS4
Alias
Leukocyte-associated immunoglobulin-like receptor 2,CD306,LAIR-2
Background
Protein LAIR2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Leukocyte Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a soluble immunoregulatory protein belonging to the immunoglobulin superfamily. LAIR2 functions primarily as a natural inhibitor of immune activation by competing with its membrane-bound counterpart, LAIR1, for binding to collagens present in the extracellular matrix. This competitive binding prevents LAIR1-mediated inhibitory signaling on immune cells such as T cells, natural killer (NK) cells, and dendritic cells, which are crucial for maintaining immune homeostasis and preventing excessive immune activation. LAIR2 is expressed predominantly in immune-related tissues, including the spleen, bone marrow, and lymph nodes, and its soluble nature allows it to circulate freely in the bloodstream, acting as a systemic modulator of collagen-induced immunosuppression. Dysregulated LAIR2 expression has been implicated in various pathological conditions, such as autoimmune diseases, where its elevated levels may counteract excessive immune inhibition, or in cancers, where it could interfere with tumor-induced immunosuppressive microenvironments. Therapeutically, LAIR2 has shown promise as a biomarker for immune dysregulation and as a potential agent in immunotherapy strategies aimed at mitigating immune suppression in cancers or promoting immune tolerance in autoimmune disorders. Its precise role and interactions with other immune checkpoints continue to be a subject of active research, with a focus on leveraging its properties for clinical applications in immune modulation.

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abx067774

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Recombinant Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Ver Producto