Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx211841
tested applications
ELISA, WB, IHC
Description
LAIR2 Antibody is a Rabbit Polyclonal against LAIR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ISS4 |
| Gene ID | 3904 |
| Alias | Leukocyte-associated immunoglobulin-like receptor 2,CD306,LAIR-2 |
| Background | Antibody anti-LAIR2 |
| Status | RUO |
Descripción
Leukocyte Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a soluble immunoregulatory protein belonging to the immunoglobulin superfamily. LAIR2 functions primarily as a natural inhibitor of immune activation by competing with its membrane-bound counterpart, LAIR1, for binding to collagens present in the extracellular matrix. This competitive binding prevents LAIR1-mediated inhibitory signaling on immune cells such as T cells, natural killer (NK) cells, and dendritic cells, which are crucial for maintaining immune homeostasis and preventing excessive immune activation. LAIR2 is expressed predominantly in immune-related tissues, including the spleen, bone marrow, and lymph nodes, and its soluble nature allows it to circulate freely in the bloodstream, acting as a systemic modulator of collagen-induced immunosuppression. Dysregulated LAIR2 expression has been implicated in various pathological conditions, such as autoimmune diseases, where its elevated levels may counteract excessive immune inhibition, or in cancers, where it could interfere with tumor-induced immunosuppressive microenvironments. Therapeutically, LAIR2 has shown promise as a biomarker for immune dysregulation and as a potential agent in immunotherapy strategies aimed at mitigating immune suppression in cancers or promoting immune tolerance in autoimmune disorders. Its precise role and interactions with other immune checkpoints continue to be a subject of active research, with a focus on leveraging its properties for clinical applications in immune modulation.
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