Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (FITC)
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935106861
info@markelab.com
Precio
162.5€ (20 µg)
Antibody anti-LAIR2
proveedor
Abbexareference
abx304325Tested Applications
reactivity
Humanstatus
RUOclonality
PolyclonalDescripción
LAIR2 Antibody (FITC) is a Rabbit Polyclonal against LAIR2 conjugated to FITC.
Background
Leukocyte Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a soluble immunoregulatory protein belonging to the immunoglobulin superfamily. LAIR2 functions primarily as a natural inhibitor of immune activation by competing with its membrane-bound counterpart, LAIR1, for binding to collagens present in the extracellular matrix. This competitive binding prevents LAIR1-mediated inhibitory signaling on immune cells such as T cells, natural killer (NK) cells, and dendritic cells, which are crucial for maintaining immune homeostasis and preventing excessive immune activation. LAIR2 is expressed predominantly in immune-related tissues, including the spleen, bone marrow, and lymph nodes, and its soluble nature allows it to circulate freely in the bloodstream, acting as a systemic modulator of collagen-induced immunosuppression. Dysregulated LAIR2 expression has been implicated in various pathological conditions, such as autoimmune diseases, where its elevated levels may counteract excessive immune inhibition, or in cancers, where it could interfere with tumor-induced immunosuppressive microenvironments. Therapeutically, LAIR2 has shown promise as a biomarker for immune dysregulation and as a potential agent in immunotherapy strategies aimed at mitigating immune suppression in cancers or promoting immune tolerance in autoimmune disorders. Its precise role and interactions with other immune checkpoints continue to be a subject of active research, with a focus on leveraging its properties for clinical applications in immune modulation.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2)
host
Rabbit
conjugation
FITC
form
Liquid
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
or code
LAIR2
dry ice
No
availability
Shipped within 5-10 working days.
alias
Leukocyte-associated immunoglobulin-like receptor 2,CD306,LAIR-2
uniprot id
NCBI accession
NP_002279.2, NM_002288.5, NP_067154.1, NM_021270.4
note
This product is for research use only.
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