Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (FITC)

Este producto es parte de LAIR2 - leukocyte associated immunoglobulin like receptor 2
Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2) Antibody (FITC)

Pida mas información

935106861

info@markelab.com

Precio

162.5€ (20 µg)

Antibody anti-LAIR2

proveedor

Abbexa

reference

abx304325

Tested Applications

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

LAIR2 Antibody (FITC) is a Rabbit Polyclonal against LAIR2 conjugated to FITC.


Background

Leukocyte Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a soluble immunoregulatory protein belonging to the immunoglobulin superfamily. LAIR2 functions primarily as a natural inhibitor of immune activation by competing with its membrane-bound counterpart, LAIR1, for binding to collagens present in the extracellular matrix. This competitive binding prevents LAIR1-mediated inhibitory signaling on immune cells such as T cells, natural killer (NK) cells, and dendritic cells, which are crucial for maintaining immune homeostasis and preventing excessive immune activation. LAIR2 is expressed predominantly in immune-related tissues, including the spleen, bone marrow, and lymph nodes, and its soluble nature allows it to circulate freely in the bloodstream, acting as a systemic modulator of collagen-induced immunosuppression. Dysregulated LAIR2 expression has been implicated in various pathological conditions, such as autoimmune diseases, where its elevated levels may counteract excessive immune inhibition, or in cancers, where it could interfere with tumor-induced immunosuppressive microenvironments. Therapeutically, LAIR2 has shown promise as a biomarker for immune dysregulation and as a potential agent in immunotherapy strategies aimed at mitigating immune suppression in cancers or promoting immune tolerance in autoimmune disorders. Its precise role and interactions with other immune checkpoints continue to be a subject of active research, with a focus on leveraging its properties for clinical applications in immune modulation.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Leukocyte Associated Immunoglobulin Like Receptor 2 (LAIR2)


host

Rabbit


conjugation

FITC


form

Liquid


purity

> 95%


purification

Purified by Protein G.


buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.


size 1

20 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


storage

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.


or code

LAIR2


dry ice

No


availability

Shipped within 5-10 working days.


alias

Leukocyte-associated immunoglobulin-like receptor 2,CD306,LAIR-2


NCBI accession

NP_002279.2, NM_002288.5, NP_067154.1, NM_021270.4


note

This product is for research use only.


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