Family main features
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a critical immune regulatory receptor found primarily on leukocytes. It belongs to the immunoglobulin superfamily and functions predominantly as an inhibitory receptor that helps modulate immune responses to prevent overactivation and maintain immune homeostasis. LAIR1 is expressed on a wide array of immune cells, including T cells, B cells, NK cells, monocytes, and dendritic cells, where it plays a fundamental role in dampening immune cell activation to limit inflammation and protect against autoimmune reactions. The receptor primarily interacts with collagen and collagen-like ligands, commonly found in extracellular matrix proteins, which allows it to exert inhibitory signals in tissues rich in collagen.
LAIR1’s role as an inhibitory receptor has garnered significant attention for its involvement in regulating immune cell activation, migration, and cytokine production. This regulatory function is crucial in autoimmune diseases, where loss of LAIR1 function can lead to unchecked immune responses. Additionally, its expression on a wide range of immune cells allows it to coordinate responses across both the innate and adaptive immune systems, and it has also been implicated in cancer immunology, particularly regarding how tumors may exploit LAIR1 signaling to evade immune detection.
LAIR1 is a single-pass type I transmembrane protein comprising distinct extracellular, transmembrane, and intracellular domains:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain:
LAIR1 belongs to the leukocyte-associated immunoglobulin-like receptor family and is part of the broader immunoglobulin superfamily (IgSF). It is closely related to LAIR2, a soluble homolog that is structurally similar but lacks a transmembrane domain. LAIR2 can bind to the same collagen ligands as LAIR1, effectively acting as a decoy by competing with LAIR1 for ligand binding. This competitive interaction can modify the regulatory functions of LAIR1 by limiting its access to collagen and other ligands.
LAIR1’s primary function is to act as an inhibitory receptor on immune cells, modulating cellular responses to maintain immune homeostasis:
Immune Regulation:
Collagen Recognition and Immune Homeostasis:
Tumor Immunology:
Autoimmune Diseases:
Role in Infection and Inflammation:
Given its significant role in immune regulation, LAIR1 is associated with several clinical conditions:
Cancer:
Autoimmune Diseases:
Chronic Inflammatory Diseases:
Infectious Diseases:
LAIR1 (leukocyte-associated immunoglobulin-like receptor 1) is a vital inhibitory receptor within the immune system that modulates the activation of various immune cells. It plays a crucial role in maintaining immune homeostasis by binding to collagen in the extracellular matrix and delivering inhibitory signals through its ITIM motifs. This inhibition is crucial for regulating immune responses, as it balances activating signals to prevent excessive inflammation and autoimmunity.
Structurally, LAIR1 is characterized by an extracellular Ig-like domain that binds collagen, a hydrophobic transmembrane domain, and an intracellular domain containing two ITIMs that recruit phosphatases, such as SHP-1 and SHP-2, to inhibit downstream activation pathways. LAIR1's interactions with collagen in the tissue environment help immune cells recognize non-inflammatory or non-danger signals, which is essential for limiting immune activity in collagen-rich tissues.
LAIR1’s dysregulation is linked to various clinical issues, including cancer, autoimmune diseases, and chronic inflammatory diseases. Its expression in the tumor microenvironment, for instance, can suppress immune responses, aiding tumor evasion. Similarly, impaired LAIR1 signaling is implicated in autoimmune conditions like systemic lupus erythematosus, where insufficient inhibitory signaling results in hyperactive immune responses. Due to these diverse roles, LAIR1 is a promising therapeutic target in immunotherapy, autoimmunity, and inflammatory diseases.
leukocyte associated immunoglobulin like receptor 1 (LAIR1)
Leukocyte-associated immunoglobulin-like receptor 1,CD305,LAIR-1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con LAIR1 - leukocyte associated immunoglobulin like receptor 1
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Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | LAIR1 | EH2427 | Human LAIR1(Leukocyte-associated immunoglobulin-like receptor 1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q6GTX8 | RUO | ||
Abbexa | LAIR1 | abx492311 | Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.129 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | LAIR1 | abx152153 | Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | LAIR1 | abx520932 | Mouse Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BG84 | RUO | |
Abbexa | LAIR1 | abx520933 | Rat Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P0C1X9 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LAIR1 | abx140530 | Immunoglobulin Heavy Chain Variable Region (LAIR1) Antibody (APC) | Human | Monoclonal | Mouse | Immunoglobulin Heavy Chain Variable Region (LAIR1) | APC | FCM | 400 | 100 tests | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx304321 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody (FITC) | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | FITC | 162.5 | 20 µg | Q6GTX8 | RUO | ||
Abbexa | LAIR1 | abx027605 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx347119 | Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) Antibody (PerCP / Cyanine 5.5) | Human | Monoclonal | Mouse | Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) | PerCP / Cyanine 5.5 | FCM | 562.5 | 100 tests | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx173344 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Monoclonal | Mouse | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | LAIR1 | abx432907 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Goat | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | LAIR1 | abx304322 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Biotin | ELISA | 162.5 | 20 µg | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx413886 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody (FITC) | Human | Monoclonal | Mouse | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | FITC | FCM | 400 | 100 µg | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx323354 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx139698 | CD305 Antibody (PE) | Human | Monoclonal | Mouse | CD305 | PE | FCM | 400 | 100 tests | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx304319 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx304320 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody (HRP) | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | HRP | ELISA | 162.5 | 20 µg | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx211417 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx136030 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | WB | 175 | 20 µl | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx139697 | CD305 Antibody | Human | Monoclonal | Mouse | CD305 | Unconjugated | WB, FCM, IP | 275 | 0.1 mg | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx104583 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q6GTX8 | RUO | |
Abbexa | LAIR1 | abx212139 | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody | Human | Polyclonal | Rabbit | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q6GTX8 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LAIR1 | abx680123 | Mouse Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein | Mouse | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | LAIR1 | abx067773 | Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q6GTX8 | RUO |
Abbexa | LAIR1 | abx690819 | Mouse Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein | Mouse | Recombinant | Human | SDS-PAGE | 212.5 | 10 µg | Q8BG84 | RUO | |
Abbexa | LAIR1 | abx691255 | Mouse Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q8BG84-6 | RUO | |
Abbexa | LAIR1 | abx692476 | Mouse Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q8BG84-1 | RUO | |
Abbexa | LAIR1 | abx261724 | Leukocyte-Associated Ig-Like Receptor 1 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q6GTX8 | RUO | ||
FineTest | LAIR1 | P6022 | Recombinant Human LAIR1 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q6GTX8 | RUO | ||
Abbexa | LAIR1 | abx694228 | Human Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | Q6GTX8 | RUO |
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