Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody
416€ (200 µl)
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935106861
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name
Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432907
tested applications
P-ELISA, WB, IHC
Description
LAIR1 Antibody is a Goat Polyclonal antibody against LAIR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3903 |
| NCBI Accession | NP_002278.1, NP_068352.1 |
| Alias | Leukocyte-associated immunoglobulin-like receptor 1,CD305,LAIR-1 |
| Background | Antibody anti-LAIR1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a critical immune regulatory receptor found primarily on leukocytes. It belongs to the immunoglobulin superfamily and functions predominantly as an inhibitory receptor that helps modulate immune responses to prevent overactivation and maintain immune homeostasis. LAIR1 is expressed on a wide array of immune cells, including T cells, B cells, NK cells, monocytes, and dendritic cells, where it plays a fundamental role in dampening immune cell activation to limit inflammation and protect against autoimmune reactions. The receptor primarily interacts with collagen and collagen-like ligands, commonly found in extracellular matrix proteins, which allows it to exert inhibitory signals in tissues rich in collagen. LAIR1’s role as an inhibitory receptor has garnered significant attention for its involvement in regulating immune cell activation, migration, and cytokine production. This regulatory function is crucial in autoimmune diseases, where loss of LAIR1 function can lead to unchecked immune responses. Additionally, its expression on a wide range of immune cells allows it to coordinate responses across both the innate and adaptive immune systems, and it has also been implicated in cancer immunology, particularly regarding how tumors may exploit LAIR1 signaling to evade immune detection.
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