Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein

Este producto es parte de LAIR1 - leukocyte associated immunoglobulin like receptor 1
Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein
195€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067773
Tested Applications
WB, SDS-PAGE

Description

Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Gln22-His163
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 19.2 kDa
Observed MW (SDS-PAGE): 24 kDa

Possible reasons why the actual band size differs from the predicted band size:
1. Splice variants. Alternative splicing may create different sized proteins from the same gene.
2. Relative charge. The composition of amino acids may affect the charge of the protein.
3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size.
4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form.
5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed.
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q6GTX8
Alias
Leukocyte-associated immunoglobulin-like receptor 1,CD305,LAIR-1
Background
Protein LAIR1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 1500 µg/ml

Background

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a critical immune regulatory receptor found primarily on leukocytes. It belongs to the immunoglobulin superfamily and functions predominantly as an inhibitory receptor that helps modulate immune responses to prevent overactivation and maintain immune homeostasis. LAIR1 is expressed on a wide array of immune cells, including T cells, B cells, NK cells, monocytes, and dendritic cells, where it plays a fundamental role in dampening immune cell activation to limit inflammation and protect against autoimmune reactions. The receptor primarily interacts with collagen and collagen-like ligands, commonly found in extracellular matrix proteins, which allows it to exert inhibitory signals in tissues rich in collagen. LAIR1’s role as an inhibitory receptor has garnered significant attention for its involvement in regulating immune cell activation, migration, and cytokine production. This regulatory function is crucial in autoimmune diseases, where loss of LAIR1 function can lead to unchecked immune responses. Additionally, its expression on a wide range of immune cells allows it to coordinate responses across both the innate and adaptive immune systems, and it has also been implicated in cancer immunology, particularly regarding how tumors may exploit LAIR1 signaling to evade immune detection.

Productos relacionados

abx027605

Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T …

Ver producto
abx067773

Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein

Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Protein is a recombinant Human protein expressed in E.…

Ver producto
abx104583

Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Antibody

Polyclonal Antibody to Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1).…

Ver producto