Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) CLIA Kit
845€ (96 tests)
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name
Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx492311
tested applications
CLIA
Description
Human Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.129 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Leukocyte-associated immunoglobulin-like receptor 1,CD305,LAIR-1 |
| Background | CLIA Kits LAIR1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a critical immune regulatory receptor found primarily on leukocytes. It belongs to the immunoglobulin superfamily and functions predominantly as an inhibitory receptor that helps modulate immune responses to prevent overactivation and maintain immune homeostasis. LAIR1 is expressed on a wide array of immune cells, including T cells, B cells, NK cells, monocytes, and dendritic cells, where it plays a fundamental role in dampening immune cell activation to limit inflammation and protect against autoimmune reactions. The receptor primarily interacts with collagen and collagen-like ligands, commonly found in extracellular matrix proteins, which allows it to exert inhibitory signals in tissues rich in collagen. LAIR1’s role as an inhibitory receptor has garnered significant attention for its involvement in regulating immune cell activation, migration, and cytokine production. This regulatory function is crucial in autoimmune diseases, where loss of LAIR1 function can lead to unchecked immune responses. Additionally, its expression on a wide range of immune cells allows it to coordinate responses across both the innate and adaptive immune systems, and it has also been implicated in cancer immunology, particularly regarding how tumors may exploit LAIR1 signaling to evade immune detection.
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