Family main features
Killer cell lectin-like receptor K1 (KLRK1), commonly known as NKG2D (natural-killer group 2 member D), is an activating receptor expressed on several immune cell types, primarily natural killer (NK) cells and certain subsets of T cells (e.g., CD8+ cytotoxic T cells and gamma-delta (γδ) T cells). KLRK1 plays a pivotal role in immune surveillance by recognizing and binding stress-induced ligands on infected, transformed, or stressed cells, ultimately promoting their elimination. Unlike other receptors that recognize pathogen-specific molecules, KLRK1 targets cells based on “stress signals” upregulated due to infection, cellular transformation, or other cellular stress.
KLRK1 serves as a crucial bridge between the innate and adaptive immune systems, offering an immediate response to transformed cells and facilitating longer-lasting adaptive immunity. This receptor is primarily involved in immune responses to tumors, viral infections, and autoimmune processes, where it mediates cytotoxic responses upon recognizing ligands that signal cellular distress or abnormality.
The KLRK1 protein structure is characterized by several key domains and motifs essential for ligand recognition and signal transduction, making it a potent activator of immune responses:
Extracellular Lectin-like Domain:
Transmembrane Domain:
Intracellular Signaling Domain:
Ligand Interaction Sites:
KLRK1 is itself a unique receptor without direct subtypes. However, its functionality can be influenced by the specific cell type on which it is expressed and by the nature of its ligands. KLRK1 ligands are classified into two primary families based on their structure and regulatory elements:
MIC Family:
ULBP Family:
The primary function of KLRK1 is to detect and eliminate cells undergoing stress, such as viral infection, transformation, or DNA damage. This is achieved through several mechanisms:
Activation of Cytotoxic Immune Responses:
Enhancing T Cell Cytotoxicity:
Surveillance and Immunoediting:
Role in Viral Infections:
Cancer:
Autoimmune Diseases:
Transplantation and Graft Rejection:
Viral Immune Evasion:
KLRK1, or NKG2D, is a critical activating receptor in immune surveillance, predominantly expressed on NK cells and subsets of T cells. It recognizes stress-induced ligands like MICA, MICB, and ULBP proteins, marking stressed, infected, or transformed cells for elimination. The KLRK1 structure, comprising an extracellular lectin-like domain, a transmembrane domain, and interaction with the DAP10 adapter, facilitates potent immune activation. Functionally, KLRK1 bridges innate and adaptive immunity, enhancing NK cell cytotoxicity and providing co-stimulatory signals to T cells.
KLRK1 is involved in tumor immunity, immunoediting, and responses to viral infections, but its dysregulation can contribute to autoimmune diseases and transplant rejection. Cancer cells often evade KLRK1-mediated immune surveillance by shedding its ligands, while some viruses reduce ligand expression to avoid detection. Clinically, targeting KLRK1 pathways holds therapeutic promise in cancer, autoimmune disorders, and viral infections, where modulating its activity can help restore immune balance and improve treatment outcomes.
killer cell lectin like receptor K1 (KLRK1)
NKG2-D type II integral membrane protein,KLR,CD314,NKG2D,NKG2-D,NK cell receptor D,NKG2-D-activating NK receptor
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | KLRK1 | abx535336 | Human NKG2-D type II integral membrane protein (KLRK1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 14.2 pg/ml | 687.5 | 96 tests | P26718 | RUO |
Abbexa | KLRK1 | abx535337 | Mouse NKG2-D type II integral membrane protein (KLRK1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O54709 | RUO | ||
Abbexa | KLRK1 | abx535339 | Rat NKG2-D Type II Integral Membrane Protein (KLRK1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O70215 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | KLRK1 | FNab10477 | Anti-KLRK1 antibody | human | polyclonal | Rabbit | NKG2-D type II integral membrane protein | IgG | Unconjugated | ELISA, WB | 100µg | P26718 | RUO | |
Abbexa | KLRK1 | abx414139 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | IHC, FCM, IP | 737.5 | 500 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx173258 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | KLRK1 | abx270010 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | FCM | 275 | 50 tests | RUO | ||
Abbexa | KLRK1 | abx323357 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx414140 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (FITC) | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | FITC | FCM | 400 | 100 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx315300 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (FITC) | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | FITC | 162.5 | 20 µg | P26718 | RUO | ||
Abbexa | KLRK1 | abx140097 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | IHC-F, FCM, IP | 275 | 0.1 mg | P26718 | RUO | |
Abbexa | KLRK1 | abx414141 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (PE) | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | PE | FCM | 487.5 | 100 tests | P26718 | RUO | |
Abbexa | KLRK1 | abx315299 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (HRP) | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | HRP | ELISA | 162.5 | 20 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx140098 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (APC) | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | APC | FCM | 400 | 100 tests | P26718 | RUO | |
Abbexa | KLRK1 | abx140096 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | IHC-F, FCM, IP, FUNC | 275 | 0.1 mg | P26718 | RUO | |
Abbexa | KLRK1 | abx130829 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | KLRK1 | abx302220 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx414138 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | IHC, FCM, IP | 462.5 | 200 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx270540 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (APC) | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | APC | FCM | 737.5 | 200 tests | RUO | ||
Abbexa | KLRK1 | abx140100 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (PE) | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | PE | FCM | 400 | 100 tests | P26718 | RUO | |
Abbexa | KLRK1 | abx315301 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (Biotin) | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Biotin | ELISA | 162.5 | 20 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx270308 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (FITC) | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | FITC | FCM | 525 | 200 tests | RUO | ||
Abbexa | KLRK1 | abx270772 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (PE) | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | PE | FCM | 625 | 200 tests | RUO | ||
Abbexa | KLRK1 | abx179027 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Monoclonal | Mouse | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | WB, IHC, IF/ICC | 1225 | 1 ml | RUO | ||
Abbexa | KLRK1 | abx323204 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx004687 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | WB | 175 | 20 µl | P26718 | RUO | |
Abbexa | KLRK1 | abx217181 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Human | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | ELISA, WB | 350 | 100 µg | P26718 | RUO | |
Abbexa | KLRK1 | abx130828 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Mouse | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O54709 | RUO | |
Abbexa | KLRK1 | abx130827 | NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody | Rat | Polyclonal | Rabbit | NKG2-D Type II Integral Membrane Protein (KLRK1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | KLRK1 | abx680087 | Human NKG2-D type II integral membrane protein (KLRK1) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | KLRK1 | abx168747 | Rat NKG2-D Type II Integral Membrane Protein (KLRK1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | O70215 | RUO |
Abbexa | KLRK1 | abx260981 | Killer Cell lectin-Like Receptor Subfamily K, Member 1 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | P26718 | RUO | ||
Abbexa | KLRK1 | abx168746 | Mouse NKG2-D Type II Integral Membrane Protein (KLRK1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | O54709 | RUO |
Abbexa | KLRK1 | abx168745 | Human NKG2-D Type II Integral Membrane Protein (KLRK1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | P26718 | RUO |
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