NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (PE)
546€ (100 tests)
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Name
NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270772
Tested Applications
FCM
Description
Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: NKG2-D Type II Integral Membrane Protein (KLRK1) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | NKG2-D type II integral membrane protein,KLR,CD314,NKG2D,NKG2-D,NK cell receptor D,NKG2-D-activating NK receptor |
| Background | Antibody anti-KLRK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Killer cell lectin-like receptor K1 (KLRK1), commonly known as NKG2D (natural-killer group 2 member D), is an activating receptor expressed on several immune cell types, primarily natural killer (NK) cells and certain subsets of T cells (e.g., CD8+ cytotoxic T cells and gamma-delta (γδ) T cells). KLRK1 plays a pivotal role in immune surveillance by recognizing and binding stress-induced ligands on infected, transformed, or stressed cells, ultimately promoting their elimination. Unlike other receptors that recognize pathogen-specific molecules, KLRK1 targets cells based on “stress signals” upregulated due to infection, cellular transformation, or other cellular stress. KLRK1 serves as a crucial bridge between the innate and adaptive immune systems, offering an immediate response to transformed cells and facilitating longer-lasting adaptive immunity. This receptor is primarily involved in immune responses to tumors, viral infections, and autoimmune processes, where it mediates cytotoxic responses upon recognizing ligands that signal cellular distress or abnormality.
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