KLRK1 antibody
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Description
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NKG2-D type II integral membrane protein (KLRK1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 30 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P26718 |
| Gene ID | 22914 |
| Alias | NKG2-D type II integral membrane protein,KLR,CD314,NKG2D,NKG2-D,NK cell receptor D,NKG2-D-activating NK receptor |
| Background | Antibody anti-KLRK1 |
| Status | RUO |
| Note | Mol. Weight 30 kDa |
Descripción
Killer cell lectin-like receptor K1 (KLRK1), commonly known as NKG2D (natural-killer group 2 member D), is an activating receptor expressed on several immune cell types, primarily natural killer (NK) cells and certain subsets of T cells (e.g., CD8+ cytotoxic T cells and gamma-delta (γδ) T cells). KLRK1 plays a pivotal role in immune surveillance by recognizing and binding stress-induced ligands on infected, transformed, or stressed cells, ultimately promoting their elimination. Unlike other receptors that recognize pathogen-specific molecules, KLRK1 targets cells based on “stress signals” upregulated due to infection, cellular transformation, or other cellular stress. KLRK1 serves as a crucial bridge between the innate and adaptive immune systems, offering an immediate response to transformed cells and facilitating longer-lasting adaptive immunity. This receptor is primarily involved in immune responses to tumors, viral infections, and autoimmune processes, where it mediates cytotoxic responses upon recognizing ligands that signal cellular distress or abnormality.
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KLRK1 Antibody is a Rabbit Polyclonal antibody against KLRK1. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
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