NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
NKG2-D Type II Integral Membrane Protein (KLRK1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130828
tested applications
WB
Description
KLRK1 Antibody is a Rabbit Polyclonal against KLRK1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: NKG2-D Type II Integral Membrane Protein (KLRK1) Immunogen: abx168746 - Recombinant KLRK1 (Phe90-Val232) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Mouse |
| Assay Type | Concentration: 0.65 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O54709 |
| Alias | NKG2-D type II integral membrane protein,KLR,CD314,NKG2D,NKG2-D,NK cell receptor D,NKG2-D-activating NK receptor |
| Background | Antibody anti-KLRK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Killer cell lectin-like receptor K1 (KLRK1), commonly known as NKG2D (natural-killer group 2 member D), is an activating receptor expressed on several immune cell types, primarily natural killer (NK) cells and certain subsets of T cells (e.g., CD8+ cytotoxic T cells and gamma-delta (γδ) T cells). KLRK1 plays a pivotal role in immune surveillance by recognizing and binding stress-induced ligands on infected, transformed, or stressed cells, ultimately promoting their elimination. Unlike other receptors that recognize pathogen-specific molecules, KLRK1 targets cells based on “stress signals” upregulated due to infection, cellular transformation, or other cellular stress. KLRK1 serves as a crucial bridge between the innate and adaptive immune systems, offering an immediate response to transformed cells and facilitating longer-lasting adaptive immunity. This receptor is primarily involved in immune responses to tumors, viral infections, and autoimmune processes, where it mediates cytotoxic responses upon recognizing ligands that signal cellular distress or abnormality.
Related Products
Mouse NKG2-D Type II Integral Membrane Protein (KLRK1) Protein
Mouse KLRK1 Protein is a recombinant Mouse protein expressed in E. coli.
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