Family main features
CLEC4A (C-type lectin domain family 4 member A), also known as DCIR (dendritic cell immunoreceptor), is a receptor found on the surface of various immune cells, particularly dendritic cells (DCs) and monocytes. CLEC4A is part of the C-type lectin receptor (CLR) family, a group of proteins that play key roles in the immune system, especially in pathogen recognition, immune homeostasis, and inflammatory responses. As a member of this family, CLEC4A can recognize and bind to carbohydrate structures found on pathogens, self-antigens, and damaged cells. This binding facilitates immune responses and communication between cells of the immune system.
CLEC4A has an important immunomodulatory role and is involved in both activating and inhibitory signaling pathways. Its ability to bind self-antigens and regulate immune responses is critical in maintaining immune tolerance, thus preventing autoimmune responses. Its expression in dendritic cells and other antigen-presenting cells highlights its relevance in adaptive immunity, where it influences T-cell activation and the shaping of immune responses. Additionally, CLEC4A is implicated in various autoimmune diseases and infections, making it an important target for therapeutic research.
CLEC4A is a transmembrane protein with a C-type lectin domain and follows the structure typical of CLRs:
Extracellular C-type Lectin-like Domain (CTLD):
Neck Region:
Transmembrane Domain:
Cytoplasmic Tail with Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM):
CLEC4A is classified under the C-type lectin domain family 4 (CLEC4), specifically within the DCIR (dendritic cell immunoreceptor) subgroup. It does not have well-documented subtypes or isoforms in humans, although there is evidence of differential expression patterns in immune cells that may indicate functional variations in different immune contexts. The CLEC4 family includes other receptors like CLEC4D and CLEC4E, each with unique roles in immune responses, but CLEC4A is unique for its ITIM-containing cytoplasmic tail, making it an inhibitory receptor.
CLEC4A plays a multifaceted role in immune regulation, with functions that include pathogen recognition, modulation of immune cell signaling, and maintenance of immune tolerance:
Pathogen Recognition:
Inhibition of Immune Responses:
Role in Adaptive Immunity and Antigen Presentation:
Maintenance of Immune Tolerance:
Autoimmune Diseases:
Infectious Diseases:
Cancer:
Chronic Inflammatory Conditions:
CLEC4A (DCIR) is a C-type lectin receptor that is essential for immune regulation, with roles in pathogen recognition, immune inhibition, and maintenance of immune tolerance. Structurally, CLEC4A is characterized by an extracellular C-type lectin-like domain for carbohydrate binding, a short neck region, a transmembrane domain, and a cytoplasmic tail with an ITIM motif that mediates inhibitory signaling. CLEC4A recognizes and binds to carbohydrates on pathogens and self-antigens, facilitating immune modulation.
CLEC4A’s functions include immune cell inhibition, antigen presentation, and immune tolerance, with significant roles in infectious disease, autoimmune regulation, and cancer. Clinically, CLEC4A is implicated in autoimmune diseases, chronic inflammation, and immune escape in cancers. As a result, CLEC4A is an important target for therapeutic research, with potential for interventions aimed at modulating immune responses in autoimmune disorders, infections, and cancer. Its ability to mediate both activation and inhibition of immune pathways underscores its versatility and significance in immune system regulation.
C-type lectin domain family 4 member A (CLEC4A)
DCIR,LLIR,CD367,DDB27,hDCIR,CLECSF6,HDCGC13P,C-type lectin DDB27,C-type lectin superfamily member 6,Dendritic cell immunoreceptor,Lectin-like immunoreceptor
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CLEC4A - C-type lectin domain family 4 member A
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Esta página contiene 12 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC4A | abx507125 | Human C-Type Lectin Domain Family 4 Member A (CLEC4A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | Q9UMR7 | RUO |
Abbexa | CLEC4A | abx507126 | Mouse C-type lectin domain family 4 member A (CLEC4A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9QZ15 | RUO | ||
Abbexa | CLEC4A | abx507127 | Rat C-Type Lectin Domain Family 4 Member A (CLEC4A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q67EQ0 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC4A | abx145939 | C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member A (CLEC4A) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | CLEC4A | abx324986 | C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member A (CLEC4A) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9UMR7 | RUO | |
Abbexa | CLEC4A | abx002065 | C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member A (CLEC4A) | Unconjugated | WB | 175 | 20 µl | Q9UMR7 | RUO | |
Abbexa | CLEC4A | abx213433 | C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member A (CLEC4A) | Unconjugated | ELISA, WB | 250 | 50 µl | Q9UMR7 | RUO | |
Abbexa | CLEC4A | abx212296 | C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member A (CLEC4A) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9UMR7 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC4A | abx693064 | Rat C-Type Lectin Domain Family 4 Member A (CLEC4A3) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q5YIS0 | RUO | |
Abbexa | CLEC4A | abx693422 | Rat C-Type Lectin Domain Family 4 Member A (CLEC4A2) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q5YIS1 | RUO | |
Abbexa | CLEC4A | abx693207 | Human C-Type Lectin Domain Family 4 Member A (CLEC4A) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 50 µg | RUO | ||
Abbexa | CLEC4A | abx693425 | Rat C-Type Lectin Domain Family 4 Member A (CLEC4B2) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q67DU9 | RUO |
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