C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody
357.5€ (100 µg)
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name
C-Type Lectin Domain Family 4 Member A (CLEC4A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145939
tested applications
ELISA, WB, IHC
Description
CLEC4A Antibody is a Rabbit Polyclonal against CLEC4A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: C-Type Lectin Domain Family 4 Member A (CLEC4A) Immunogen: Recombinant fragment corresponding to 3-225 AA of human CLEC4A. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 28 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_016184.3, NM_194447.2, NM_194448.2, NM_194450.2 |
| Alias | DCIR,LLIR,CD367,DDB27,hDCIR,CLECSF6,HDCGC13P,C-type lectin DDB27,C-type lectin superfamily member 6,Dendritic cell immunoreceptor,Lectin-like immunoreceptor |
| Background | Antibody anti-CLEC4A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
CLEC4A (C-type lectin domain family 4 member A), also known as DCIR (dendritic cell immunoreceptor), is a receptor found on the surface of various immune cells, particularly dendritic cells (DCs) and monocytes. CLEC4A is part of the C-type lectin receptor (CLR) family, a group of proteins that play key roles in the immune system, especially in pathogen recognition, immune homeostasis, and inflammatory responses. As a member of this family, CLEC4A can recognize and bind to carbohydrate structures found on pathogens, self-antigens, and damaged cells. This binding facilitates immune responses and communication between cells of the immune system. CLEC4A has an important immunomodulatory role and is involved in both activating and inhibitory signaling pathways. Its ability to bind self-antigens and regulate immune responses is critical in maintaining immune tolerance, thus preventing autoimmune responses. Its expression in dendritic cells and other antigen-presenting cells highlights its relevance in adaptive immunity, where it influences T-cell activation and the shaping of immune responses. Additionally, CLEC4A is implicated in various autoimmune diseases and infections, making it an important target for therapeutic research.
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