Family main features
CD33, also known as Siglec-3 (Sialic acid-binding Ig-like lectin 3), is a transmembrane receptor expressed primarily on cells of myeloid lineage. It belongs to the immunoglobulin (Ig) superfamily and plays a significant role in the regulation of innate immunity. CD33 was first identified in the late 1980s as a marker on acute myeloid leukemia (AML) cells, making it a focal point for research in hematological malignancies. This glycoprotein is encoded by the CD33 gene located on chromosome 19q13.3. CD33 is involved in cellular signaling processes that modulate immune cell function and survival.
CD33 is a type I transmembrane protein comprising several distinct domains:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic Tail:
CD33 is a member of the Siglec family, which are cell surface receptors that recognize sialic acid-containing glycoconjugates. Siglecs are classified based on their structure and function into two major groups:
Immune Regulation:
Phagocytosis:
Hematopoiesis and Leukemia:
Neuroinflammation:
Acute Myeloid Leukemia (AML):
Autoimmune Diseases:
Neurodegenerative Disorders:
CD33 is a crucial regulator of immune cell function, playing significant roles in the modulation of phagocytosis, immune response, and hematopoiesis. Its structure, featuring an extracellular domain with sialic acid-binding capacity and a cytoplasmic tail with ITIM motifs, facilitates its inhibitory signaling functions. Clinically, CD33 is most notable for its expression in AML and its potential as a therapeutic target. Additionally, CD33's involvement in autoimmune diseases and neuroinflammation highlights its broader significance in health and disease. Ongoing research into CD33's mechanisms and therapeutic targeting continues to expand our understanding of its role in immune regulation and its potential in clinical applications.
CD33 molecule (CD33)
p67,SIGLEC3,SIGLEC-3,CD33rSiglec,Sialic acid-binding Ig-like lectin 3,Myeloid cell surface antigen CD33
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con CD33 molecule
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 51 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CD33 | EH3782 | Human SIGLEC3(Sialic Acid Binding Ig Like Lectin 3) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | P20138 | RUO | ||
Abbexa | CD33 | abx195376 | Human Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | CD33 | abx253174 | Human Myeloid Cell Surface Antigen CD33 / SIGLEC3 (CD33) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 525 | 96 tests | P20138 | RUO |
Abbexa | CD33 | abx555397 | Human Myeloid Cell Surface Antigen CD33 (CD33) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | P20138 | RUO | |
FineTest | CD33 | EMK0072 | Monkey SIGLEC3(Sialic Acid Binding Ig Like Lectin 3) ELISA Kit | monkey | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | A0A2K5W2R5 | RUO | ||
FineTest | CD33 | EM1363 | Mouse SIGLEC3(Sialic Acid Binding Ig Like Lectin 3) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q63994 | RUO | ||
Abbexa | CD33 | abx490783 | Mouse Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.057 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | CD33 | abx254421 | Mouse Myeloid Cell Surface Antigen CD33 / SIGLEC3 (CD33) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 525 | 96 tests | Q63994 | RUO |
Abbexa | CD33 | abx154676 | Mouse Myeloid Cell Surface Antigen CD33 / SIGLEC3 (CD33) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CD33 | FNab01467 | anti- CD33 antibody | human | polyclonal | Rabbit | CD33 molecule | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | P20138 | RUO | |
Abbexa | CD33 | abx321577 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | P20138 | RUO | |
Abbexa | CD33 | abx336630 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (Biotin) | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Biotin | ELISA | 162.5 | 20 µg | P20138 | RUO | |
Abbexa | CD33 | abx015798 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, IHC, FCM | 362.5 | 100 µl | P20138 | RUO | |
Abbexa | CD33 | abx010522 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA | 362.5 | 100 µl | P20138 | RUO | |
Abbexa | CD33 | abx015799 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC, FCM | 362.5 | 100 µl | P20138 | RUO | |
Abbexa | CD33 | abx025513 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IF/ICC | 250 | 80 µl | P20138 | RUO | |
Abbexa | CD33 | abx027453 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB | 250 | 80 µl | P20138 | RUO | |
Abbexa | CD33 | abx028674 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | P20138 | RUO | |
Abbexa | CD33 | abx320368 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | P20138 | RUO | |
Abbexa | CD33 | abx336629 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (FITC) | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | FITC | 162.5 | 20 µg | P20138 | RUO | ||
Abbexa | CD33 | abx412913 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (PE) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | PE | FCM | 487.5 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx211129 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P20138 | RUO | |
Abbexa | CD33 | abx323358 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P20138 | RUO | |
Abbexa | CD33 | abx338481 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | P20138 | RUO | |
Abbexa | CD33 | abx412909 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (APC) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | APC | FCM | 487.5 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx412911 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (FITC) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | FITC | FCM | 400 | 100 µg | P20138 | RUO | |
Abbexa | CD33 | abx412915 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | WB, FCM, IP | 175 | 25 µg | P20138 | RUO | |
Abbexa | CD33 | abx111477 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC, IF/ICC | 612.5 | 100 µl | P20138 | RUO | |
Abbexa | CD33 | abx336628 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (HRP) | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | HRP | ELISA | 162.5 | 20 µg | P20138 | RUO | |
Abbexa | CD33 | abx231467 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | P20138 | RUO | |
Abbexa | CD33 | abx139239 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | WB, IHC-F, IF/ICC, FCM, IP | 275 | 0.1 mg | P20138 | RUO | |
Abbexa | CD33 | abx139238 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | WB, IHC-F, IF/ICC, FCM, IP, FUNC | 275 | 0.1 mg | P20138 | RUO | |
Abbexa | CD33 | abx139242 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (FITC) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | FITC | FCM | 350 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx347055 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (PE / Cyanine 5) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | PE / Cyanine 5 | FCM | 400 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx347108 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (PerCP / Cyanine 5.5) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | PerCP / Cyanine 5.5 | FCM | 562.5 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx139237 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | FCM | 287.5 | 0.1 mg | P20138 | RUO | |
Abbexa | CD33 | abx139240 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (Biotin) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | Biotin | FCM | 350 | 0.1 mg | P20138 | RUO | |
Abbexa | CD33 | abx139241 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (PerCP) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | PerCP | FCM | 400 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx347004 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (APC / Cyanine 7) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | APC / Cyanine 7 | FCM | 437.5 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx140943 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (APC / Cyanine 7) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | APC / Cyanine 7 | FCM | 437.5 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx139243 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (PE) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | PE | FCM | 400 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx139244 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody (APC) | Human | Monoclonal | Mouse | Myeloid Cell Surface Antigen CD33 (CD33) | APC | FCM | 400 | 100 tests | P20138 | RUO | |
Abbexa | CD33 | abx211749 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P20138 | RUO | |
Abbexa | CD33 | abx001676 | Myeloid Cell Surface Antigen CD33 (CD33) Antibody | Human | Polyclonal | Rabbit | Myeloid Cell Surface Antigen CD33 (CD33) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | P20138 | RUO | |
Abbexa | CD33 | abx129608 | Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Antibody | Mouse | Polyclonal | Rabbit | Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q63994 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD33 | abx680006 | Human Myeloid Cell Surface Antigen CD33 / SIGLEC3 (CD33) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CD33 | abx261278 | Myeloid Cell Surface Antigen CD33 (CD33) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | P20138 | RUO | ||
Abbexa | CD33 | abx692457 | Mouse Myeloid Cell Surface Antigen CD33 (CD33) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 412.5 | 20 µg | Q63994-1 | RUO | |
Abbexa | CD33 | abx694129 | Human Myeloid Cell Surface Antigen CD33 (CD33) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 400 | 20 µg | P20138 | RUO | |
Abbexa | CD33 | abx167216 | Mouse Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO | |
Abbexa | CD33 | abx691369 | Human Myeloid Cell Surface Antigen CD33 (CD33) Protein | Human | Recombinant | Human | SDS-PAGE | 200 | 10 µg | P20138 | RUO |
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