Family main features
NOS1AP (neuronal nitric oxide synthase adaptor protein) is a crucial adaptor protein involved in the regulation of nitric oxide (NO) signaling in neurons. It specifically interacts with neuronal nitric oxide synthase (nNOS or NOS1), which produces NO, a critical signaling molecule in the nervous system. NO plays key roles in neurotransmission, neuroplasticity, and neurovascular regulation. NOS1AP modulates the activity and localization of nNOS, influencing various physiological processes and contributing to the regulation of cellular signaling pathways in the brain.
NOS1AP is characterized by several functional domains that facilitate its interactions with other proteins and its role in signaling pathways:
NOS1AP belongs to the family of PDZ domain-binding proteins, which interact with PDZ domain-containing proteins to form signaling complexes. While NOS1AP is primarily known for its interaction with nNOS, it may also interact with other proteins involved in cellular signaling.
NOS1AP plays several critical roles in neuronal signaling and function:
Dysregulation or mutations in NOS1AP are associated with several clinical conditions:
NOS1AP (neuronal nitric oxide synthase adaptor protein) is an adaptor protein that plays a crucial role in regulating neuronal nitric oxide synthase (nNOS) and NO signaling in the nervous system. Structurally, NOS1AP features a PDZ-binding motif at the C-terminus, which facilitates its interaction with nNOS. This interaction modulates the localization and activity of nNOS, influencing NO production and various downstream signaling pathways involved in neurotransmission, synaptic plasticity, and neurodevelopment. Dysregulation of NOS1AP is associated with cardiovascular diseases, neurological disorders, and psychiatric conditions. Understanding the functions and mechanisms of NOS1AP in NO signaling provides insights into its potential as a therapeutic target for these conditions.
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP)
NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | NOS1AP | EH15009 | Human NOS1AP (Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | O75052 | RUO | ||
Abbexa | NOS1AP | abx555974 | Human Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 687.5 | 96 tests | O75052 | RUO | |
Abbexa | NOS1AP | abx556154 | Mouse Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9D3A8 | RUO | |
Abbexa | NOS1AP | abx555899 | Rat Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein (NOS1AP) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | O54960 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | NOS1AP | abx317052 | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (HRP) | Human | Polyclonal | Rabbit | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) | HRP | ELISA | 162.5 | 20 µg | O75052 | RUO | |
Abbexa | NOS1AP | abx128689 | Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Antibody | Human | Polyclonal | Rabbit | Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | O75052 | RUO | |
Abbexa | NOS1AP | abx122667 | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody | Human | Polyclonal | Rabbit | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | NOS1AP | abx302365 | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody | Human | Polyclonal | Rabbit | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | O75052 | RUO | |
Abbexa | NOS1AP | abx025659 | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody | Human | Polyclonal | Rabbit | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) | Unconjugated | ELISA, WB, FCM | 281.25 | 80 µl | O75052 | RUO | |
Abbexa | NOS1AP | abx317053 | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (FITC) | Human | Polyclonal | Rabbit | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) | FITC | 162.5 | 20 µg | O75052 | RUO | ||
Abbexa | NOS1AP | abx317054 | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (Biotin) | Human | Polyclonal | Rabbit | Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) | Biotin | ELISA | 162.5 | 20 µg | O75052 | RUO | |
Abbexa | NOS1AP | abx129363 | Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Antibody | Mouse | Polyclonal | Rabbit | Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NOS1AP | abx166175 | Mouse Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | NOS1AP | abx166176 | Human Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | O75052 | RUO |
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